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As per available reports about 3 Conference Proceedings, 1 National symposium is presently dedicated exclusively to Genome editing and about 3 Open Access Articles are being published on Genome editing.
Genome editing is a type of genetic engineering in which DNA is inserted, replaced, or removed from a genome using artificially engineered nucleases, or "molecular scissors." The nucleases create specific double-stranded break (DSBs) at desired locations in the genome, and harness the cell’s endogenous mechanisms to repair the induced break by natural processes of homologous recombination (HR) and nonhomologous end-joining (NHEJ). There are currently four families of engineered nucleases being used: Zinc finger nucleases (ZFNs), Transcription Activator-Like Effector Nucleases (TALENs), the CRISPR/Cas system, and engineered meganuclease re-engineered homing endonucleases.It is commonly practiced in genetic analysis that in order to understand the function of a gene or a protein function one interferes with it in a sequence-specific way and monitors its effects on the organism. However, in some organisms it is difficult or impossible to perform site-specific mutagenesis, and therefore more indirect methods have to be used, such as silencing the gene of interest by short RNA interference (siRNA) .Yet gene disruption by siRNA can be variable and incomplete. Genome editing with nucleases such as ZFN is different from siRNA in that the engineered nuclease is able to modify DNA-binding specificity and therefore can in principle cut any targeted position in the genome, and introduce modification of the endogenous sequences for genes that are impossible to specifically target by conventional RNAi. Furthermore, the specificity of ZFNs and TALENs are enhanced as two ZFNs are required in the recognition of their portion of the target and subsequently direct to the neighboring sequences.
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Scope and Importance:
Genome editing offers a greater degree of control and precision in how specific DNA sequences are changed. It could be used in basic science, for human health, or improvements to crops. There are a variety of techniques but clustered regularly inter-spaced short palindromic repeats, or CRISPR, is perhaps the foremost.
The global genome editing market is expected to reach $3,514.08 Million by 2019 from $1,845.25 Million in 2014, at a CAGR of 13.75% between 2014 and 2019. Factors such as rapid increase in the number of pharmaceutical and biotechnology industries, strong trend of R&D in life science research, increasing government funding for genomics, technological advancements, increased demand for synthetic genes, and the overall rise in the production of genetically modified crops are driving the growth of the genome editing market. On the other hand, stringent regulatory policies and ethical issues are major factors restraining the growth of this market.
1. 3rd Genomics and Pharmacogenomics Conference; September 21-23, 2015 in San Antonio, USA
2. 6th Genomics and Pharmacogenomics Conference; September 22-24, 2016 at Berlin, Germany
3. Genetic Counseling and Genomic Medicine Conference; August 11-12, 2016 Birmingham, UK
4. 2nd Tissue Preservation and Biobanking Conference; August 18-19, 2016 in Portland, USA
5. 4th Integrative Biology Conference; July 18-20, 2016, in Hotel Ramada, Berlin, Germany
6. 10th Asia-Pacific Biotech Conference; July 25-27, 2016 at Bangkok, Thailand
7. Clinical and Molecular Genetics conference; November 28-30, 2016 in Chicago, USA
8. 12th Biotechnology Conference; November 14-15, 2016 at San Francisco, USA
9. World Bio conference; November 02-04, 2015 at Dubai, UAE
Association and societies
1. National center for genome research
2. Northeast Structural Genomics Consortium
3. North Carolina Genomics & Bioinformatics Consortium
4. International Genomics Consortium
5. Translational genomics research institute
6. The institute for genome research
7. Australian genome research facility
1. Genetic Technologies Group
3. Ambry Genetics
4. BioSpyder Technologies
5. Predictive Biology
7. Color Genomics
8. Agena Bioscience
This page will be updated regularly.
This page was last updated on April 2, 2020