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Liposome is a spherical vesicle having at least one lipid bilayer. The liposome can be used as a vehicle for administration of nutrients and pharmaceutical drugs. Liposomes can be prepared by disrupting biological membranes (such as by sonication). Liposomes are most often composed of phospholipids, especially phosphatidylcholine, but may also include other lipids, such as egg phosphatidylethanolamine, so long as they are compatible with lipid bilayer structure. A liposome design may employ surface ligands for attaching to unhealthy tissue. Liposomes are extensively used in drug designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes can be widely used in Drug Delivery systems like Vaccine Drug Delivery, Oral Drug Delivery, Ocular Drug Delivery, BBB Drug Delivery Systems, and also in Nanosystems like Nanosomes, Micro emulsions.
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Scope and Importance:
Their rapid development arises from the ability to overcome the drawbacks of the currently employed therapeutic drugs, which exhibit poor biopharmaceutical and pharmacokinetic properties. Nanoparticle drug carriers provide alternative formulation strategies for those molecules thus enhancing the scope for commercialization. They are potential for prolonged drug release. The conference too offers growth to expand reserves of knowledge and explore newer realms.
Liposomes are microparticulate lipoidal vesicles which are under extensive investigation as drug carriers for improving the delivery of therapeutic agents. Composed of relatively biocompatible and biodegradable material and they consist of an aqueous volume entrapped by one or more bilayers of natural and/or synthetic lipids. Lipids, along with proteins and nucleic acids, are essential biomolecules for the structure and function of living matter. Most lipids are fats and waxes, but this thesis focuses on so-called amphiphilic lipids. This type of lipid is the predominant building block of biological membranes, as well as liposomes.
Liposomes are spherical self-closed structures, composed of curved lipid bilayers, which enclose part of the surrounding solvent into their interior. The size of a liposome ranges from some 20 nm up to several micrometers and they may be composed of one or several concentric membranes, each with a thickness of about 4 nm. Liposomes possess unique properties owing to the amphiphilic character of the lipids, which make them suitable for drug delivery. Drugs with widely varying lipophilicities can be encapsulated in liposomes, either in the
On the basis of the ability of liposomes to interact with cells and/or blood components, at least two types of liposomes currently can be designed
Liposomes can be classified in terms of composition and mechanism of intracellular delivery into five types as:
The global liposomes market is projected at a CAGR of 13.15%, through 2005-2020. The market for liposomes presents attractive growth opportunities, driven by growing demand for increasingly effective drugs in the field of pharmaceuticals, and niche applications in other emerging areas. Liposome drug delivery systems have been instrumental in the formulation of potent drugs to enhance therapeutics.
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This page was last updated on 11th Sep, 2015
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