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Glomerular filtration rate is a test used to check how well the kidneys are working. Specifically, it estimates how much blood passes through the glomeruli each minute. Glomeruli are the tiny filters in the kidneys that filter waste from the blood. Measurement of the GFR can be very helpful to medical professionals. It helps them decide if a person has a disease of the kidneys or not. A normal value for GFR is between 90-110ml/min. This will normally go down in older people. It will also go down in people with kidney disease. As well as helping a medical professional diagnose a kidney disease, the GFR is also used to monitor the progress of a disease. The GFR can be determined by injecting inulin or the inulin-analog sinistrin into the plasma. Since both inulin and sinsitrin, are neither reabsorbed nor secreted by the kidney after glomerular filtration, their rate of excretion is directly proportional to the rate of filtration of water and solutes across the glomerular filter. Compared to the MDRD formula, the inulin clearance slightly overestimates the glomerular function. In early stage renal disease, the inulin clearance may remain normal due to hyper filtration in the remaining nephrons. Incomplete urine collection is an important source of error in inulin clearance measurement. The GFR can be determined by injecting inulin or the inulin-analog sinistrin into the plasma. Since both inulin and sinsitrin, are neither reabsorbed nor secreted by the kidney after glomerular filtration, their rate of excretion is directly proportional to the rate of filtration of water and solutes across the glomerular filter. Compared to the MDRD formula, the inulin clearance slightly overestimates the glomerular function. In early stage renal disease, the inulin clearance may remain normal due to hyperfiltration in the remaining nephrons. Incomplete urine collection is an important source of error in inulin clearance measurement.
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This page was last updated on April 19, 2024