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As per available reports about 6 Relevant journals, 28 Conferences,71 National Symposiums are presently dedicated exclusively to Diabetic Insipidus and about 449 articles are being published on Diabetic Insipidus.
Diabetes Insipidus is an uncommon condition in which the kidneys are unable to prevent the excretion of water. During the day it causes your kidneys filter all your blood many times. Normally, most of the water is reabsorbed, and only a small amount of concentrated urine is excreted. DI occurs when the kidneys cannot concentrate the urine normally, and a large amount of dilute urine is excreted. The amount of water excreted in the urine is controlled by antidiuretic hormone (ADH). ADH is also called vasopressin. ADH is produced in a part of the brain called the hypothalamus. It is then stored and released from the pituitary gland. This is a small gland at the base of the brain. DI caused by a lack of ADH is called central diabetes insipidus. When DI is caused by a failure of the kidneys to respond to ADH, the condition is nephrogenic diabetes Insipidus.
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Scope and importance
It is important for people with diabetes insipidus to work with their doctors to accurately diagnose the severity of the condition and the underlying cause, and to decide on the form of treatment. In cases of nephrogenic diabetes insipidus, medications are used to reduce the volume of urine passed, while the levels of salts (such as sodium) in the blood must be monitored closely. Dietary changes may be advised. As with central diabetes insipidus, excessive amounts of watery (dilute) urine are passed and excessive thirst causes a high intake of fluids. If, however, inadequate fluids are consumed the excessive amounts of dilute urine passed may cause dehydration. Data on the number of clinical trials conducted in North America, South and Central America, Europe, Middle-East and Africa.
Diabetes Insipidus is an uncommon condition in which the kidneys are unable to prevent the excretion of water.
Causes: During the day, your kidneys filter all your blood many times. Normally, most of the water is reabsorbed, and only a small amount of concentrated urine is excreted. DI occurs when the kidneys cannot concentrate the urine normally, and a large amount of dilute urine is excreted.
The amount of water excreted in the urine is controlled by antidiuretic hormone (ADH). ADH is also called vasopressin. ADH is produced in a part of the brain called the hypothalamus. It is then stored and released from the pituitary gland. This is a small gland at the base of the brain.
DI caused by a lack of ADH is called central diabetes insipidus. When DI is caused by a failure of the kidneys to respond to ADH, the condition is called nephrogenic diabetes Insipidus .
Central Diabetes Insipidus :
Nephrogenic DI involves a defect in the kidneys. As a result, the kidneys do not respond to ADH. Like central DI, nephrogenic DI is very rare. Nephrogenic DI may be caused by:
Symptoms of DI include:
Exam & Test:
The health care provider will ask about your medical history and symptoms. Tests that may be ordered include:
The cause of the underlying condition will be treated when possible. Central diabetes insipidus may be controlled with vasopressin (desmopressin, DDAVP). You take vasopressin as an injection, a nasal spray, or tablets. If nephrogenic DI is caused by medication, stopping the medication may help restore normal kidney function. But with some medications, such as lithium, after many years of use, nephrogenic DI can be permanent. Hereditary nephrogenic DI and lithium-induced nephrogenic DI are treated by drinking enough fluids to match urine output. Medicines that lower urine output also need to be taken. Nephrogenic DI is treated with anti-inflammatory medicines and diuretics (water pills).
Possible Complications: If your body's thirst control is normal and you drink enough fluids, there are no significant effects on body fluid or salt balance. Not drinking enough fluids can lead to dehydration and electrolyte imbalance. If DI is treated with vasopressin and your body's thirst control is not normal, drinking more fluids than your body needs can cause dangerous electrolyte imbalance.
Global Data’s clinical trial report, Diabetes Insipidus Global Clinical Trials Review, H1, 2014" provides data on the Diabetes Insipidus clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Diabetes Insipidus. It includes an overview of the trial numbers and their recruitment status as per the site of trial conduction across the globe. The datebook offers a preliminary coverage of disease clinical trials by their phase, trial status, prominence of the sponsors and also provides briefing pertaining to the number of trials for the key drugs for treating Diabetes Insipidus. This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by Global Data’s team of industry experts.v
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