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Ethosomes are the major advances in vesicle research. Ethosomes are soft vesicles made of phospholipids and ethanol (in higher quantity) and water. Ethosomes are non-invasive delivery carriers that enable drugs to reach the deep skin layers and/or the systemic circulation. Ethosomes are soft, malleable vesicles composed mainly of phospholipids (phosphatidyl choline, phosphatidyl serine, and phosphatitidic acid), ethanol (relatively high concentration) and water. These “soft vesicles” represents novel vesicular carrier for enhanced delivery through skin. The soft, malleable vesicles tailored for enhanced delivery of active agents. The size of ethosomes can be modulated to range anywhere from 30nm to a few microns. Although ethosomal systems are conceptually sophisticated, they are characterized by simplicity in their preparation, safety and efficacy that can highly expand their application.
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Scope and Importance:
Ethosomes are mainly used for the delivery of drugs through transdermal route. The transdermal delivery is one of the most important routes of drug administration. The main factor which limits the application of transdermal route for drug delivery is the permeation of drugs through the skin. Human skin has selective permeability for drugs. Lipophilic drugs can pass through the skin but the drugs which are hydrophilic in nature can’t pass through. There are two methods which can be used for the formulation and preparation of ethosomes. Both of the methods are very simple and convenient and do not involve any sophisticated instrument or complicated process.
It can be easily concluded that ethosomes can provide better skin permeation than liposomes. The main limiting factor of transdermal drug delivery system i.e. epidermal barrier can be overcome by ethosomes to significant extent. Application of ethosomes provides the advantages such as improved permeation through skin and targeting to deeper skin layers for various skin diseases. Ethosomes have been tested to encapsulate hydrophilic drugs, cationic drugs, proteins and peptides. Ethosomal carrier opens new challenges and opp
Ethosomal systems were much more efficient at delivering a fluorescent probe to the skin in terms of quantity and depth than either liposomes or hydro alcoholic solution. Ethosomes provides a number of important benefits including improving the drug's efficacy, enhancing patient compliance, comfort and reducing the total cost of treatment. Ethosomes were found to be suitable for various applications within the pharmaceuticals, biotechnology, veterinary, cosmetic and nutraceutical markets. Enhanced delivery of bioactive molecules through the skin and cellular membranes by means of an ethosomal carrier opens numerous challenges and opportunities for the research and future development of novel improved therapies. Ethosomes are lipid vesicles containing phospholipids, alcohol (ethanol and isopropyl alcohol) in relatively high concentration and water.
According to IMS Health Consulting, an international research company, in 2012 the size of the global pharmaceutical market reached $940 billion. In monetary terms it grew by 6%. In the future the sector is expected to grow at no less than 3% to 4% a year and if this happens the global pharmaceutical market is expected to reach $1.1 trillion by 2015 and will reach $1.2 trillion in 2016 and up to $1.5 trillion by 2020. The global demographic, epidemiological and economic changes are transforming the pharmaceutical market. The world population is growing rapidly and is projected to raise from 7 billion in 2011 to 7.7 billion in 2020 and 9.6 billion in 2050, hence an increase in the demand for pharmaceuticals.
International symposium and workshops
1. 5th PCNE Working Symposium 2016, Hillerød, Denmark, 19-20 February 2016.
2. 8th Pharma Sciences symposium, Osaka, Japan, 21-22 January 2016.
3. ISOPP 2016, Santiago, Chile, April 17-20, 2016.
Relevant Society and Associations
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This page was last updated on 10th Sep, 2015
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