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Ultrasomes are UV-endonuclease enzymes encapsulated in multilamellar liposomes. Endonuclease is prepared from Micrococcus luteus. Natural DNA repair activity for humans is facilitated by endonuclease, which is the enzyme in ultrasomes. Ultrasomes also protect the immune system by repairing UV-DNA damage and reducing the expression of TNF “, IL-1, IL-6 and IL-8. Endonuclease recognizes UV damage and is reported to accelerate its repair four-fold. Liposomes (200 nanometers) are formed from pure and 100% natural egg phospholipids. Interestingly, ultrasomes also stimulate the production of melanin by melanocytes in the tanning response following UV exposure.
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Scope and Importance:
Ultrasomes reduce fine lines, wrinkles and the grey tired look damaged skin can have. Ultrasomes may be used as delivery agents to facilitate transfer of cosmetically active agents into the dermis of skin, such as the DNA repair enzymes or the plant or botanical ingredients of the present invention. Other delivery agents may be used for dermal delivery in place of the ultrasomes, including, but not limited to skin delivery vehicles known to those skilled in the art, including emulsions, microemulsions, nanoemulsions, nanoparticles, microspheres, ethosomes, transfersomes, and niosomes
UV radiation from the sun may also damage DNA and may bring about several detrimental effects including cell death, mutation and neoplastic transformation. Studies indicate that some of these deleterious effects are due to the formation of two major classes of bipyrimidine DNA photoproducts, cyclobutane pyrimidine dimers (CPDS) and (6-4) photoproducts (6-4 PPs). Organisms have evolved several different pathways for removing CPDs and 6-4 PPs from cellular DNA. These pathways include various excision repair pathways which can be highly specific or nonspecific for CPDs and 6-4 PPs. Ultrasomes recognizes UV damage in the underlying layer of the epidermis and speeds the repair cycle to minimize hyper pigmentation. In view of the many detrimental effects impacting the skin, there is a demand for cosmetic compositions and cosmetic methods for improving the appearance and condition of skin. Consumers seek “anti-aging” cosmetic products that treat or delay the visible signs of actual aging and weathered skin, such as wrinkles, lines, sagging, hyperpigmentation and age spots. Consumers also seek other benefits from cosmetic products in addition to anti-aging benefits. For example, the concept of “sensitive skin” has raised the demand for cosmetic products that improve the appearance and condition of sensitive, dry and/or flaky skin, and that soothe red, and/or irritated skin. Consumers also desire cosmetic products that treat spots, pimples, blemishes, and the like, or that reduce the risk of skin cancer. Ultrasomes deliver a milk derived enzyme that exfoliates and nourishes the skin simultaneously.
According to IMS Health Consulting, an international research company, in 2012 the size of the global pharmaceutical market reached $940 billion. In monetary terms it grew by 6%. In the future the sector is expected to grow at no less than 3% to 4% a year and if this happens the global pharmaceutical market is expected to reach $1.1 trillion by 2015 and will reach $1.2 trillion in 2016 and up to $1.5 trillion by 2020. The global demographic, epidemiological and economic changes are transforming the pharmaceutical market. The world population is growing rapidly and is projected to raise from 7 billion in 2011 to 7.7 billion in 2020 and 9.6 billion in 2050, hence an increase in the demand for pharmaceuticals.
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