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Therapeutic vaccine is a potentially promising means for the treatment of chronic hepatitis B in clinic, yet no is available at present. ÎµPA44 is a de novo designed mimogen that acts as a tri-epitope integrated immunogen in order to prime therapeutic immunity while avoiding harmful and unnecessary immunity. To prove the mimogen concept, we performed a randomized, doseâ€“escalation trial in 56 normal healthy research volunteers and a randomized, doubleâ€“blind, placeboâ€“controlled trial in 46 patients in two centers in China
Although mass inoculation with preventive vaccines have drastically decreased the prevalence of hepatitis B virus (HBV)infection in a few countries, the pool of post-exposure population worldwide remains essentially unchanged. Therapeutic vaccine is a potentially promising means for the treatment of chronic hepatitis B in clinic, yet no is available at present. ÎµPA44 is a de novo designed mimogen that acts as a tri-epitope integrated immunogen in order to prime therapeutic immunity while avoiding harmful and unnecessary immunity. To prove the mimogen concept, we performed a randomized, doseâ€“escalation trial in 56 normal healthy research volunteers and a randomized, doubleâ€“blind, placeboâ€“controlled trial in 46 patients in two centers in China. ÎµPA44 was well tolerated and safe in all participants, and induced designed immune responses that included vigorous HBV-specific CTLs, anti-Pre-S(2) antibodies, Th1 cytokines, and downregulated regulatory T cells. ÎµPA44 might also decrease serum viral load of HBV and conduce serum HBeAg/HBeAb seroconversion in patients, which could persist to week 252 without relapse. Our findings highlight the potential of mimogen strategy for treating patients with chronic infections.
OMICS International Organizes 1000+ Global Events Every Year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 700+ Open access journals which contains over 100000 eminent personalities, reputed scientists as editorial board and organizing committee members. The conference series website will provide you list and details about the conference organize worldwide.
• American Society for Microbiology
• Society for Applied Microbiology- UK
• International Union of Microbiological Societies
• Society for General Microbiology Journals
• American Society for Microbiology Career Connections
• The Canadian Society of Microbiologists
• European Microbiological Society.
• Illinois Society of Microbiology
• British Society for Microbial Technology
• New Zealand Microbological Society
• Merck & Co.
• Johnson & Johnson
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This page was last updated on 15th Sep, 2015
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