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As per available reports about 10 relevant journals, 15 Conferences, 30 workshops are presently dedicated exclusively to structural Biology and about 2,070 articles are being published on Structural Biology
Structural biology can help us to see some of the detail missing from this view and consequently is a powerful tool to unpick the intricate and exquisite choreography of life. For centuries, we have been able to visualise structures inside a cell, but even the most powerful microscopes are limited in the detail they provide, either by the sheer physical boundaries of magnification, or because the samples themselves are not alive and working. Structural biology methods delve beneath these limits bringing molecules to life in 3D and into sharper focus. It reaches to the very limits of how a molecule works and how its function can be modified.
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Scope and Importance
The process of determining molecular structure can be long and frustrating – sometimes taking years. Mostly, proteins are the targets for structure analysis as these are the main ‘doing’ molecules of the cell. Proteins are built from a DNA template and the string of amino acids thus synthesized fold into very complex loops, sheets and coils – it might seem like a tangle, but this structure dictates how the protein will interact with other structures around it in order to undertake its duties in the cell. The elegant structures of molecules and the complexes they form can be breathtaking in their logic and symmetry, but they are also supreme in helping us to understand how cells actually work. Suddenly shapes, sizes and assemblies of molecules can be assigned to various compartments in cells and put into context with their surrounding environment. A key aim of structural cell biology is to build a landscape representation of cellular function. The emergent picture will be akin to a sophisticated and dynamic metropolis where molecular relationships are forged and broken, short- or long-lived and all are shaped by the inevitability of cell reproduction, aging and death. To discover the 3D structure of a protein, the most common route is to crystallise it. This stabilises many identical protein molecules in a crystal lattice which, when bombarded with X-rays, provides diffraction data giving valuable information on the spatial relationships of atoms in the protein. From these data, the 3D structure can be built, from scratch if necessary, but more commonly in today’s structural biology laboratories, by comparison with other similar structures. The resulting image of a protein structure can depict its size, how it is folded up, what the overall ‘shape’ is and where any special ‘decorations’ are attached. These images are, of course, artificial; a protein doesn’t actually look like the images generated, the reality of protein structure in nature being dynamic and therefore more indistinct. Some proteins are hard or impossible to crystallise in which case other techniques can be used to determine the structure. These other methods such as nuclear magnetic resonance, microscopy, electron tomography or mass spectroscopy give different views of proteins at different scales. So to get the richest and most accurate 3D structure of a protein, all of these techniques can be brought together to produce a protein structure that gives more information than just the space it fills. This is correlative structural biology – correlating information from many techniques into one structure that can tell you how the protein works, where it fits inside (or outside) the cell and which other molecules it interacts with. This view of a small part of the cell landscape can be used to identify proteins or even specific parts of proteins that can be targets of designer drugs; perhaps to disable a dysfunctional protein or to modify its behaviour. Structural biology can therefore bring unique information to drug or vaccine discovery programmes and be used thereafter to correlate efficacy with the specific changes at an atomic level. It is a key foundation for modern strategies to improve health for the future. Structural biology is a branch of molecular biology, biochemistry, and biophysics concerned with the molecular structure of biological macromolecules, especially proteins and nucleic acids, how they acquire the structures they have, and how alterations in their structures affect their function. This subject is of great interest to biologists because macromolecules carry out most of the functions of cells, and because it is only by coiling into specific three-dimensional shapes that they are able to perform these functions. This architecture, the "tertiary structure" of molecules, depends in a complicated way on the molecules' basic composition, or "primary structures. "Hemoglobin, the oxygen transporting protein found in red blood cells. Biomolecules are too small to see in detail even with the most advanced light microscopes. The methods that structural biologists use to determine their structures generally involve measurements on vast numbers of identical molecules at the same time. Structural biology centers: • In America there are more than 300 structural biology centers and institutes were there, around 11 centers were in Asia, more than 400 centers were there in Europe countries, 100 and more centers in Africa, around 35 centers and institutes were in Australia.
The analysts forecast the global bioinformatics market to grow at a CAGR of 19.49% over the period 2014-2019.The global bioinformatics market can be divided into three segments: platforms, tools, and services. To calculate the market size, the report considers the revenue generated from the three geographies: Americas, EMEA, and APAC.
International symposium and workshops
1. 10th Asia-Pacific Biotech Congress, July 25-27, 2016 Bangkok, Thailand
2. 4th Plant Genomics Conference, July 14-15, 2016 Brisbane, Australia
4. Synthetic Biology Conference, September 28-30, 2015 Houston, USA
5. Human Genetics Congress, October 31- November 02, 2016 Valencia, Spain
7. Biomaterials conference March 14-16, 2016 London, UK
9. 6th Biotechnology Congress, October 05-07, 2015, New Delhi, India
10. 12th Biotechnology Congress, November 14-15, 2016 San Francisco, USA
11. Veterinary Microbiology 2016, Sept 15-17, 2016 San Antonio, USA
15. 6th Bioinformatics Conference, March 29-30, 2016 Valencia, Spain
16. 7th Bioinformatics conference, October 27-28, 2016 Chicago, USA
19. 5th Biodiversity Conference, March 10-12, 2016 Madrid, Spain
20. Protein Engineering Conference , October 26-28, 2015, Chicago, USA
Relevant Society and Associations
This page will be updated regularly.
This page was last updated on December 4, 2021