Biography

Dr. Rumyantsev went to the Leningrad Institute of Vaccines and Sera to work on the biomechanics of anti-infectious defense. He was fortunate to be able to pursue his interest in the development of principles and means to differentiate individual states of genetic immunity or susceptibility to infections in human and animals.

Abstract

Present communication unites the results of further development of new paradigm about the biology of human cancer: the hypothesis of parasitic nature, origin and evolution of the phenomenon. Development was performed by supplementing and supporting the hypothesis by data which could not be applied before. The supplementation included integrative reconsidering, and reinterpretation of the make-ups, traits and processes existing both in human and animal cancers. It was evidenced that human cancer possesses the same set of traits characteristic of transmissible animal cancer. Undoubted analogies are seen in the prevalence, clinical exposure, progression of disease, origin of causative agents, immune response against invasion and especially in the intrinsic deviations of the leading traits of cancerous cells. Exhaustive evidence of the parasitic nature and evolutionary origin of human cancer was revealed and interpreted. In contrast to animal cancer formed of solitary cell lineage, human cancer consists of a couple of lineages constructed under different genetic regulations and performed different structural and physiological functions. The complex make-up of cancer composition remains stable over sequential propagation. The subsistence of human cancer regularly includes obligatory rotation of its successive forms including genomic, gametic, zygotic, micro-population and tumorous ones. Human cancer possesses its own biological schedule and the ability to gobble its victim, transmit via the intrusion of the genome, and perform intercommunications within the tumor components and between the dispersed subunits of individual cancer. Such intrinsic traits characterize human cancer as a primitively structured parasite that can be classified in Class Mammalians, Species Genomeintruder malevolent (G.malevolent).