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Protease inhibitors are metabolized by enzymes in the liver and can interact with other medications by speeding up or slowing down their processing in the body. Ritonavir, in particular, is a strong inhibitor of these liver enzymes and slows the processing of many other drugs. Protease inhibitors may be classified either by the type of protease they inhibit, or by their mechanism of action. In 2004 Rawlings and colleagues introduced a classification of protease inhibitors based on similarities detectable at the level of amino acid sequence. This classification initially identified 48 families of inhibitors that could be grouped into 26 related superfamily (or clans) by their structure. According to the MEROPS database there are now 85 families of inhibitors. These families are named with an I followed by a number, for example, I14 contains hirudin-like inhibitors.
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Scope and Importance
HIV protease inhibitors block the activity of the protease enzyme by breaking up large polyproteins into the smaller pieces required for assembly of new viral particles, and so is used in random clinical trials. While HIV can still replicate in the presence of protease inhibitors, the resulting virions are immature and unable to infect new cells.
Classes of Proteases are:
• Aspartic protease inhibitors
• Cysteine protease inhibitors
• Metalloprotease inhibitors
• Serine protease inhibitors (serpins)
• Threonine protease inhibitors
• Trypsin inhibitors
Protein crystallization is the most crucial and the largest segment, and it accounted for 47% of the market in 2013. On the basis of products, the protein crystallization market has segments such as reagents/consumables and instruments. Reagents/consumables accounted for 85% of the protein crystallization & crystallography product market. It is expected to grow at a high CAGR of 11% over the forecast period. The global market was valued at $775 million in 2013 and is expected to reach $1,253 million by 2018.
In medicine, protease inhibitor is often used interchangeably with alpha 1-antitrypsin (A1AT, which is indeed the protease inhibitor most often involved in disease, namely in alpha 1-antitrypsin deficiency. Second-generation protease inhibitors (atazanavir, darunavir, fosamprenavir, lopinavir, and tipranavir) work against HIV variants that have developed resistance to older drugs in this class. Darunavir and tipranavir differ from the others in that they are synthetic nonpeptidic drugs.
1. Nuclic Acids Conference
August 4-6, 2016, Seattle, USA
2. Synthetic Biology Conference
September 28-30, 2015, Houston, USA
3. Protein Engineering Conference
October 26-28, 2015, Chicago, USA
5. 2nd Transcriptomics Conference
August 15-17, 2016, Portland, USA
7. 3rd Clinical Pharmacy Conference
December 07-09, 2015, Atlanta, USA
8. 4th Integrative Biology Conference
June 13-15, 2016, Berlin, Germany
10. 5th Computational Systems Biology Conference
August 22-23, 2016, Philadelphia, USA
11. 5th Metabolomics Conference
May 16-18, 2016, Osaka, Japan
12. 6th Metabolomics Conference
November 28-30, 2016, Florida, USA
13. 6th Proteomics Conference
March 29-30, 2016, Atlanta, USA
14. 6th Bioinformatics Conference
March 29-30, 2016, Valencia, Spain
15. 7th Proteomics Conference
October 10-12, 2016, Rome, Italy
16. EMBO Practical Course to Targeted proteomics: Experimental design and data analysis
Sept 28-Oct 03, 2014 Barcelona, Spain
17. HUPO 2015 to HUPO 14th Annual World Congress
Sep 26-30, 2015 Vancouver, Canada
Related Societies and Associations
1. American Society for mass Spectrometry
2. Austrian Proteomics Society
3. American Electrophoresis Society
4. British Mass Spectrometry Society
5. California Separation Science Society
6. Canadian Mass Spectrometry Society
7. Danish Mass Spectrometry Society
8. European Proteomics Association
9. US Human Proteome Organization
10. Proteomics and Electrophoresis Societies
11. Spanish Proteomics Society– (Seprot)
12. Netherlands Proteomic Platform (Npp)
13. Japan Human Proteome Organisation (Jhupo)
14. Italian Proteomic Association (Itpa)
15. Portugese Proteomic Association (Rede Procura)
16. Iranian Proteomic Society
17. Taiwan Proteomic Society (Tps)
18. Human Proteome Organization
19. Italian Proteomics Association
20. Portuguese Proteomics Association
1. Caprion Proteomics
2. Applied Proteomics, Inc.
4. PTM Biolabs Inc
5. Biotech Support Group
6. BiognoSYS AG
8. Sera Proteomics
9. Protein Metrics Inc.
10. MRM Proteomics Inc.
11. Agilent Technologies
13. Thermo Fischer Scientific
14. Ab Sciex
15. Abbott Laboratories
17. Ams Biotechnology
18. Avacta Life Sciences
19. Bd Biosciences
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This page was last updated on April 3, 2020