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Pharmacogenomics is the study of the role of genetics in drug response. It deals with the effect of genetic variation on drug response in patients by associating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects.
Pharmacogenomics is the study of the role of genetics in drug response. It deals with the effect of genetic variation on drug response in patients by associating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The word pharmacogenomics is frequently used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and proteomics whilst dealing with the effects of multiple genes on drug response. Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments.
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Scope & Importance:
Pharmacogenomics explores the role of genetic variation in the effects of drugs and xenobiotic substances on the body, and in the body’s reactions to drugs publishing basic, translational, and pharmaceutical research. Pharmacogenetics refers to the study of DNA sequence variation as it relates to differential drug response in individuals, i.e. the use of genomics to determine an individual’s response. It refers to the use of DNA-based genotyping in order to target pharmaceutical agents to specific patient populations in the design of drugs.
Pharmacogenetics is the study of genetic causes of individual variations in drug response; pharmacogenomics more broadly involves genome-wide analysis of the genetic determinants of drug efficacy and toxicity. Primary candidate genes of interest include those encoding for drug receptors, metabolizing enzymes, and transporters. However, selection of optimal drug therapy may also involve disease susceptibility genes indirectly affecting drug response. Moreover, pharmacogenomics includes the identification of suitable targets for drug discovery and development.
Related Societies & Associations
1.HumGen: Centre for Genomics Policy, affiliated with McGill University Génome Québec Innovation Centre, Montreal, Quebec
2. The Centre for Applied Genomics, Toronto, Ontari
3. Department of Genetics, University of Cambridge
4. The Jackson Laboratory, Bar Harbor
5. American Association of Pharmaceutical Scientists
6. American Medical Association
Genomic Companies :
2. Genetic Technologies Group
4. Ambry Genetics
5. Biospyder Technologies
6. Predictive biology
8. Cypher Genomics
9. Agena Bioscience
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This page was last updated on 15th Sep, 2015
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