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Recommended Conferences for ORF-1 product Rep

ORF-1 product Rep

As per available reports about 4 open access articles, 1 conferences, 1 national symposiums are presently dedicated exclusively to ORF1 and about 1 speakers gave presentations on ORF1.

ORF-1 product Rep in helps  in  prevention and diagnosis of Porcine circovirosis. PORCINE CIRCOVIRUS DISEASES (PCVD) PMWS (Postweaning multisystemic wasting sindrome) is one of the main causes of economical losses in swine production market. Diagnosis: detection of PCV2 in the lesions (Porcine circovirus type 2). PCV2 infection is wide spread in farms. Only pigs with a high PCV2 load develop the illness due to defective humoral response. Economical loss produced by PMWS (Post weaning multisystem wasting syndrome) is one of the most important issues that concern the pig industry. PMWS is considered a multifactorial disease in which development Porcine circovirus 2 (PCV2) is essential but not sufficient. Besides PMWS, PCV2 infection has been associated with some other pathological outcomes in pigs, collectively named porcine circovirus diseases (PCVD). PCV2 is a small non-enveloped virus belonging to Circoviridae family. Its genomic organization consists of two head to head arranged open reading frames (ORF1 and ORF2) separated by an origin of replication

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ORF2 encodes the structural capsid-forming protein Cap, the main immunogenic antigen of the virus. PCV2 infection is spread in farms all over the world. However, only a small percentage (4-30%) of infected animals develop PMWS. This fact has been related to the efficiency of host immune system humoral response. In order to fight against PCV2 infection spread in farms, it is essential to vaccinate the animals and to detect, as soon as possible, a PCV2 outbreak. Our preliminary results in overexpression in E. coli and purification of the protein encoded by ORF-1, Rep, are hereby showed. Use of Rep in vaccines against PCV2 would improve their efficacy and would allow developing test to differenciate vacunated from infected pigs (DIVA) .

Polycistronic transcripts are considered rare in the human genome. Initiation of translation of internal ORFs of eukaryotic genes has been shown to use either leaky scanning or highly structured IRES regions to access initiation codons. Studies on mammalian viruses identified a mechanism of coupled translation termination–reinitiation that allows translation of an additional ORF. Here, the ribosome terminating translation of ORF-1 translocates upstream to reinitiate translation of ORF-2. We have devised an algorithm to identify mRNAs in the human transcriptome in which the major ORF-1 overlaps a second ORF capable of encoding a product of at least 50 aa in length. This identified 4368 transcripts representing 2214 genes.

Relevant Conferences:

  1. Lipid Science & Technology conference,                                                    November 30-December 02, 2015 San Francisco, USA
  2. 6th Euro Virology conference, March 10-12, 2016 Madrid, Spain
  3. 8th Pharmaceutics & Novel Drug Delivery Systems conference,                         March 07-09, 2016 Madrid, Spain 
  4. Advances in HPLC and Chromatography Techniques conference,                      March 17-18, 2016 London, UK 
  5. Industrial Pharmacy conference, April 11-12, 2016 Dubai, UAE
  6. 7th Pharmacovigilance & Clinical Trials conference,                                     September 19-21, 2016 Vienna, Austria     
  7. Environmental Microbiology Conference, Aug 4-6, 2016 Frankfurt, Germany 
  8. 2nd Pharmacology and Ethnopharmacology conference,                                        May 02-04, 2016 Chicago, USA     
  9. 2nd Therapeutic Drug Monitoring and Toxicogenomics conference,                      June 09-10, 2016 Dallas, USA 
  10. Drug Formulation & Bioavailability Congress,  June 06-08, 2016 Beijing, China 
  11. Generic Drug Market and Contract Manufacturing Conference,                             Oct 31- Nov 02, 2016 Valencia, Spain 
  12. 5th Toxicology & Applied Pharmacology Conference,                                     September 19-21, 2016 Las Vegas, USA      
  13. Cheminformatics and System Chemistry Conference,                                              July 14-15, 2016 Brisbane, Australia   
  14. Biochemistry conference, October 13-15, 2016 Kuala Lumpur, Malaysia 
  15. 4th Medicinal Chemistry & Computer Aided Drug Designing conference,      November 02-04, 2015 Atlanta, USA
  16. Polymer Chemistry conference, November 14-16, 2016 Atlanta, USA 
  17. 3rd Clinical Pharmacy conference, December 07-09, 2015 Atlanta, USA
  18. Amino Acids and Proteins Conference, December 08-09, 2016 Baltimore, USA 
  19. Nuclear Chemistry conference, October 17-19, 2016 Rome, Italy
  20. Pharma Middle East Conference, November 02-04, 2015 Dubai, UAE
  21. Lipids, Molecular & Cellular Biology of Gordon Research Conference,                    July 26-31, 2015 Waterville Valley, NH
  22. 13th Euro Fed Lipid Congress "Fats, Oils and Lipids: New Challenges in Technology, Quality Control and Health" 27-30 September 2015, Florence, Italy
  23. Influenza Vaccines for the World,                                                                             6-9 October 2015 Sao Rafael Atlantic Hotel, Albufeira, Algarve, Portugal
  24. The 2015 Vaccine Summit,                                                                                 13th - 15th October 2015 Cineworld: The O2, Peninsula Square, London
  25. Conference on 3Rs Alternatives and Consistency Testing in Vaccine Lot Release Testing, 16 -18 September 2015 Hotel Zuiderduin, The Netherlands
  26. Meningitis and Septicaemia in Children and Adults,                                             4th - 5th November 2015 Royal Society of Medicine, London, United Kingdom

Relevant Societies :

  1. Infectious Diseases Society of America
  2. International Society for Infectious Diseases
  3.  Southern African HIV Clinicians Society
  4. Australian Federation Aids Organizations
  5. ANTIAIDS Foundation
  6. Apparel Lesotho Alliance to fight AIDS
  7. AIDS Action Committee of Massachusetts
  8. AIDS Foundation Houston
  9. Infectious Diseases Society of America (IDSA)
  10. Antimicrobial resistance - Royal Society

Relevant Companies :

  1. Ranbaxy
  2. Dr Reddys Laboratories limited
  3. Lupin
  7. Cadila Healthcare Ltd
  8. Glaxo smithkline
  9. Wockhardt
  10. Sun Pharmaceutical
  11. Abbot India Ltd
  12. Torrent Pharmaceuticals Ltd
  13. Aurobindo Pharma Ltd
  14. Zydus Cadila
  15. Mankind Pharma Ltd

This page will be updated regularly.

This page was last updated on 11th Sep, 2015

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