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As per available reports about 37 relevant journals, 120 Conference proceedings, 23 workshops are presently dedicated exclusively to Glycoproteins and about 1,270 articles are being published on Glycoproteins.
Glycoproteins are proteins that contain oligosaccharide chains covalently attached to polypeptide side-chains polypeptide side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycosylation. Secreted extracellular proteins are often glycosylated. In proteins that have segments extending extracellularly, the extracellular segments are also glycosylated. Glycoproteins are often important integral membrane proteins, where they play a role in cell–cell interactions. Glycoproteins are also formed in the cytosol, but their functions and the pathways producing these modifications in this compartment are less well understood. Glycoproteins found in the body are mucins, which are secreted in the mucus of the respiratory and digestive tracts. Sugars when attached to mucins give them considerable water-holding capacity and also make them resistant to proteolysis by digestive enzymes.
Scope and importance of Glycoproteins:
Glycoproteins play an important part in hormone function. The action of hormones depends on the initial binding of the hormone to a protein receptor molecule. In many cases this molecule is a glycoprotein. Many hormones bind to receptors in the cell membrane; these hormones never actually enter the cell. Glycoproteins are important for white blood cell recognition, especially in mammals, glycoproteins consist of a polypeptide covalently bonded to a carbohydrate moiety. The carbohydrate can make up anywhere from less than one percent to more than 80 percent of the total protein mass. The saccharide chains, referred to as glycans, can be linked to the polypeptide in two major ways. The first class of glycoproteins are the O-linked glycans. These usually contain an N-acetylgalactosamine which is attached through a glycosidic bond to the O-terminus of either threonine or serine. The other class of glycoproteins are the N-linked glycans. These involve a glycosidic bond between N-acetylglucosamine and the N-terminus of an asparagine residue.
Market Analysis of Glycoproteins:
The global glycomics market was valued at $512.38 million in 2014 and poised to grow at a CAGR of 12.62% between 2012 and 2019, to reach $928.11 million in 2019. The rapid increase in research and development expenditure by pharmaceutical and biotech companies, and increased funding in proteomics and glycobiology research will be the two most important growth drivers for this market in the forecast period (2012–2019). Moreover, the rise in chronic and infectious diseases such as cancer, Alzheimer’s, Parkinson’s, and infectious diseases like herpes and AIDS will further drive research on these ailments, thus increasing the demand for glycomics products.The growth of the proteomics market will also drive the global glycomics market, on account of the large overlap in the instruments section of both markets.
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10th Global Diabetes Congress
July 14-16, 2016 Cologne, Germany
International Conference on Metabolic Syndromes
October 20-22, 2016 Dubai, UAE
Relevant Societies and Associations:
1. The Association of Bimolecular Resource Facilities (ABRF), Bethesda, MD, USA
2. American Society of Gene and Cell Therapy, Milwaukee, Wisconsin, USA
3. Triangle Chromatography Discussion Group, USA
4. American Chemical Society
5. American Society for Microbiology, USA
6. RNA Society - Maryland, USA
7. University of Nebraska Medical Centre, Omaha, Nebraska, USA
8. US HUPO, Santa Fe, New Mexico, USA
9. The Protein Society, USA
10. Society for Industrial Microbiology and Biotechnology, Fairfax, Virginia, USA
11. Federation of American Societies for Experimental Biology (FASEB), Maryland, USA
12. BioFlorida- Life Science Community
13. European Society of Human Genetics, Vienna, Austria
14. European Proteimcs Association (EuPA), UK
15. British Society for Proteome Research (BSPR), UK
16. Swiss Proteomics Society (SPS), Switzerland
17. Proteomics Society, India
1. Affymetrix - Santa Clara, California USA
2. Roche NimbleGen Inc. Madison, Wisconsin, United States
3. SciGene Sunnyvale, California, United States
4. Arrayit Corporation
5. DNAmicroarray California, USA
6. LC Sciences, Houston, TX, US
7. SeqWright Genomic Services (a unit of GE health care)
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This page was last updated on February 7, 2023