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As per available reports about 10 relevant journals, 15 Conferences, 30 workshops are presently dedicated exclusively to catabolite repression and about 2,070 articles are being published on Catabolite repression.
Carbon catabolite repression, or simply catabolite repression, is an important part of global control system of various bacteria and other micro-organisms. Catabolite repression allows micro-organisms to adapt quickly to a preferred (rapidly metabolisable) carbon and energy source first. This is usually achieved through inhibition of synthesis of enzymes involved in catabolism of carbon sources other than the preferred one. The catabolite repression was first shown to be initiated by glucose and therefore sometimes referred to as the glucose effect. However, the term "glucose effect" is actually a misnomer since other carbon sources are known to induce catabolite repression.
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Scope and Importance
The phenomenon of catabolite repression is widely used by a number of industrially important microorganisms. For example Corynebacterium glutamicum is used in the fermentation industry because of its ability of large scale amino acid production particularly glutamate and lysine. It has been found that corynebacterial strains allows access to unconventional carbon sources and therefore can produce a wide range of industrially relevant compounds. Metabolic engineering technology can be used for the utilization of alternative carbon sources i.e. sources coming from wastes and unprocessed sources and therefore C. glutamicum strains can be constructed for the production of new products such as diamines, organic acids and alcohols. Thus catabolite repression technology has significant impacts on fermentation industry.
Catabolite repression refers to the inhibition of enzyme synthesis involved in catabolism of carbon sources other than the desired sugar sources. Bacteria have distinct preferences among potential carbon sources when they are offered a choice. When glucose is available as an energy source, it is used in preference to other sugars. So for example when E.coli finds both glucose and lactose in media, it metabolizes glucose and represses the use of lactose and this result in diauxic growth. The ability of glucose to inhibit the synthesis of certain enzymes is called as glucose effect, which was recognized by Monod.
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This page was last updated on 12th Sep, 2015
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