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Coagulation (clotting) is the process by which blood changes from a liquid to a gel. It potentially results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. The mechanism of coagulation involves activation, adhesion, and aggregation of platelets along with deposition and maturation of fibrin. Disorders of coagulation are disease states which can result in bleeding (hemorrhage or bruising) or obstructive clotting (thrombosis). Coagulation is highly conserved throughout biology; in all mammals, coagulation involves both a cellular (platelet) and a protein (coagulation factor) component. The system in humans has been the most extensively researched and is the best understood.Coagulation begins almost instantly after an injury to the blood vessel has damaged the endothelium lining the vessel. Exposure of blood to the space under the endothelium initiates two processes: changes in platelets, and the exposure of subendothilial tissue factor to plasma Factor VII, which ultimately leads to fibrin formation. Platelets immediately form a plug at the site of injury; this is called primary hemostasis. Secondary hemostasis occurs simultaneously: Additional coagulation factors or clotting factors beyond Factor VII, respond in a complex cascade to form fibrin strands, which strengthen the platelet plug. Platelet Activation and von Willebrand Factor (vWF)
In order for hemostasis to occur, platelets must adhere to exposed collagen, release the contents of their granules, and aggregate. The adhesion of platelets to the collagen exposed on endothelial cell surfaces is mediated by von Willebrand factor (vWF). Inherited deficiencies of vWF are the causes of von Willebrand disease, (vWD) (also see below for more details). The function of vWF is to act as a bridge between a specific glycoprotein complex on the surface of platelets (GPIb-GPIX-GPV) and collagen fibrils. The GPIb part of the complex is composed of two proteins, GPIbα and GPIbβ encoded by separate genes. The importance of this interaction between vWF and the GPIb-GPIX-GPV complex of platelets is demonstrated by the inheritance of bleeding disorders caused by defects in three of the four proteins of the complex, the most common of which is Bernard-Soulier syndrome. In addition to its role as a bridge between platelets and exposed collagen on endothelial surfaces, vWF binds to and stabilizes coagulation factor VIII. Binding of factor VIII by vWF is required for normal survival of factor VIII in the circulation. von Willebrand factor is a complex multimeric glycoprotein that is produced by and stored in the α-granules of platelets. It is also synthesized by megakaryocytes and found associated with subendothelial connective tissue.
OMICS Group International is an amalgamation of Open Access publications and worldwide international science conferences and events. Established in the year 2007 with the sole aim of making the information on Sciences and technology ‘Open Access’, OMICS Group publishes 400 online open access journals in all aspects of Science, Engineering, Management and Technology journals. OMICS Group has been instrumental in taking the knowledge on Science & technology to the doorsteps of ordinary men and women. Research Scholars, Students, Libraries, Educational Institutions, Research centers and the industry are main stakeholders that benefitted greatly from this knowledge dissemination. OMICS Group also organizes 300 International conferences annually across the globe, where knowledge transfer takes place through debates, round table discussions, poster presentations, workshops, symposia and exhibitions.OMICS Group International ventured into Scientific Alliance, has already signed agreement with more than 1000 scientific associations worldwide to make health care and scientific information open access. This brings together a platform for global networking among the community through shared resources and working together in multifarious key areas. Now OMICS Group is going to organize International Conference on Thrombosis and Hemostasis in Beijing, China on July 13-15, 2015.
Thrombosis and Hemostasis Summit of North America (THSNA)
7th Symposium on Hemostasis
60th Annual SSC Meeting of the ISTH
FASEB Summer Research Conference on Proteases in Hemostasis & Vascular Biology
The 15th International Congress on Anti phospholipid Antibody
International Coagulation Meeting (ISTH 2013)
International Conference on Thrombosis and Hemostasis Issues in Cancer (ICTHIC)
Related association and SOCIETIES:
International Society on Thrombosis and Haemostasis (ISTH)
American Society of Hematology (ASH)
American Heart Association (AHA)
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This page was last updated on July 2, 2020