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Rubella virus (RuV) is the pathogenic agent of the disease rubella, and is the cause of congenital rubella syndrome when infection occurs during the first weeks of pregnancy.Rubella virus is the only member of the genus Rubivirus and belongs to the family of Togaviridae, whose members commonly have a genome of single-stranded RNA of positive polarity which is enclosed by an icosahedral capsid.The molecular basis for the causation of congenital rubella syndrome are not yet completely clear, but in vitro studies with cell lines showed that rubella virus has an apoptotic effect on certain cell types. There is evidence for a p53-dependent mechanism. The name "rubella" is derived from Latin, meaning "'Little Red'. Rubella also known as German measles because the disease was first described by German physicians in the mid-18th century. This disease is often normal & passes unnoticed.
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Scope and Importance:
Rubella — commonly known as German measles or 3-day measles — is an infection that mostly affects the skin and lymph nodes. It is caused by the rubella virus (not the same virus that causes measles).Rubella spreads when people breathe in virus-infected fluid, such as the droplets sprayed into the air when a person with rubella sneezes or coughs, or share food or drink with someone who's infected. It also can pass through a pregnant woman's bloodstream to infect her unborn child.It's a generally mild disease in children; the primary medical danger of rubella is the infection of pregnant women because it can cause congenital rubella syndrome in developing babies.
Before a vaccine against rubella became available in 1969, rubella epidemics happened every 6-9 years, usually among kids 5 to 9 years old, along with many cases of congenital rubella. Thanks to immunization, there are far fewer cases of rubella and congenital rubella. Most rubella infections today appear in young, non-immunized adults rather than in kids. In fact, experts estimate that 10% of young adults are currently susceptible to rubella, which could pose a danger to any children they might have someday.
Rubella infection may begin with 1-2 days of mild fever (99-100°F, 37.2-37.8°C) and swollen, tender lymph nodes, usually in the back of the neck or behind the ears. A rash then begins on the face and spreads downward. As it spreads, it usually clears on the face. The global rubella market will grow from nearly $3.8 billion in 2012 to $4 billion in 2013. Global influenza market to be worth $6.3 billion in 2014 for a compound annual growth rate (CAGR) of 2.7%.This year, the global market for products used in the fight against influenza will be worth an estimated $5.5 billion, according to a new technical market research report, the Global Rubella Market, from BCC Research. Market revenue is forecast to increase at a five-year compound annual growth rate (CAGR) of 8% from 2013 to 2018, totalling nearly $6 billion in 2018.
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Relevant Society and Associations:
1. The Measles & Rubella Intiatives
2. Rubella – World Health Organization
3. Genome – Wide SNP accociations
4. HLA-DR class2 Association
5. Canadian Deafblind and rubella Association
6. Association of Austistic Spectrum Disorder
7. Rubella, Congential – NORD
8. American Public Health Association
9. United Nations foundation
Research and Market: Rubella Therapeutics Pipeline
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This page was last updated on 14th Sep, 2015
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