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Polymer microspheres can be employed in rate control drug delivery targeted manner. Medication is released from a microsphere by drug leaching from the polymer or by degradation of the polymer matrix. Since the rate of drug release is controlled by size and area exposed to the medium , preparation of microspheres from monomers or from linear polymers affect the formation, structure, and morphology of the spheres and in drug delivery. Topics including the effects of molecular weight, blended spheres, crystallinity, drug distribution, porosity, and sphere size are discussed in relation to the characteristics of the release process. Added control over release profiles can be obtained by the employment of core-shell systems and pH-sensitive spheres. Polyethylene, polystyrene and expandable microspheres are the most common types of polymer microspheres. Biocompatible and Biodegradable Nanoparticles as Drug Carriers, niosomes, resealed erythrocytes, nanoparticles, nanospheres, naocapsules , and modified Drug Carrier Systems are the wings included in Novel Drug Delivery Systems
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Polymer Microspheres is a revolutionary field of micro manufacturing involving physical and chemical changes to produce micro-sized materials. Microsized particles consists of aggregated as well as unbound particles. Microlevel particulate drug delivery deals with processes that occur at molecular and atomic level.It involves designing, synthesis and characterization of material structure by controlling the shapes and sizes at microscale. Changing the properties of the material such as increase in surface area, dominance of quantum effects often associated with minute sizes, higher surface area to volume ratio etc. Microparticulate drug delivery systems have designed for chronotherapeutic topical drug delivery but attempts to utilize them for oral, pulmonary and parenteral drug delivery were also made. Researchers have extensively studied their properties and characteristics affecting the drug release and loading.
Polymer microspheres can be employed to deliver medication in a rate-controlled and sometimes targeted manner. Medication is released from a microsphere by drug leaching from the polymer or by degradation of the polymer matrix. Since the rate of drug release is controlled by these two factors, it is important to understand the physical and chemical properties of the releasing medium. This review presents the methods used in the preparation of microspheres from monomers or from linear polymers and discusses the physio-chemical properties that affect the formation, structure, and morphology of the spheres. Topics including the effects of molecular weight, blended spheres, crystallinity, drug distribution, porosity, and sphere size are discussed in relation to the characteristics of the release process.
Polystyrene microspheres are typically used in biomedical applications due to their ability to facilitate procedures such as cell sorting and immunio precipitation. Proteins and ligands adsorb onto polystyrene readily and permanently, which makes polystyrene microspheres suitable for medical research and biological laboratory experiments.
Polyethylene microspheres are commonly used as permanent or temporary filler. Lower m.pt enables create porous structures in ceramics and other materials and high sphericity,availability of colored and fluorescent microspheres, makes them highly desirable for flow visualization, fluid flow analysis, microscopy techniques, health sciences, process troubleshooting and numerous research applications.
Expandable microspheres are used as a blowing agent in e.g. puff ink, automotive underbody coatings and injection molding of thermoplastics, lightweight fillers.
The global revenue for advanced drug delivery systems is estimated to be $151.3 billion in 2013. In 2018, revenues are estimated to reach nearly $173.8 billion, demonstrating a compound annual growth rate (CAGR) of 2.8%. The global market for drug delivery systems in 2010 was $131.6 billion and is expected to increase to $137.8 billion by the end of 2011. The market is expected to rise at a compound annual growth rate (CAGR) of 5% and reach nearly $175.6 billion by 2016. An overview of the global market for drug delivery systems, including the market as seen by end users of different applications. Analyses of global market trends, with data from 2012, estimates for 2013, and projections of compound annual growth rates (CAGRs) through 2018
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