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Phytosomes are advanced and novel form of botanicals and phytoconstituents that are better absorbed both orally, topically and transdermally. Phytosomes have improved pharmacokinetics and pharmacological parameters and having wide scope in cosmeticology. Phytosomes possess better drug entrapment efficiency. Phytosomes can be used for systemic targeting of herbal drugs, as phytosomes can easily transit from hydrophilic environment into the lipid friendly environment of the enterocyte cell membrane and this is a new patented technology, where standardized plant extracts or water soluble phytoconstituents are complexed with phospholipids to produce lipid compatible molecular complexes, there by greatly increasing absorption and bioavailability. Phosphatidyl choline, phosphatidyl serine, phosphatidyl ethanolamine, phosphatidyl inositol are the phospholipids used, but phosphatidyl choline are widely used because of their certain therapeutic value in case of liver diseases, alcoholic steatosis, drug induced liver damage and hepatitis. Phospholipids are also employed as natural digestive aids and as carriers for both fat miscible and water miscible nutrient.
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Scope and Importance:
The enhanced bioavailability of phytoconstituents by transdermal route is a major breakthrough in the research of transdermal drug delivery systems(TDDS). TDDS involves the delivery of therapeutic agent via skin in to the systemic circulation. The stratum corneum, which is the outermost horny layer, provides the major hindrance for drug delivery due to its lipophilicity. The phytosomal form of the phytoconstituent is helpful in avoiding this barrier property. Phytosome technology has enough potency to be used transdermally for increasing bioavailability of phytoconstituents.
Phytosomes can easily traverse the lipophilic path of the entero hepatic cell membranes and also stratum corneum layer of the skin. Numerous researches are being conducted by the researchers and the recent researches reveals that the phytosome technology is a novel method for improving the absorption and bioavailability of plant extracts significantly reducing the dose level. Some plant extracts are getting more focus now-a-days due to their potential pharmacological effects, such as, silymarin, grape seed extract, quercetin, curcumin, hesperetin, ginkgo biloba extract, andrographolide etc.The suitability of this technique and increased demand of herbal medicines for various disease management in current scenario, has paved the way of newer researches.
According to IMS Health Consulting, an international research company, in 2012 the size of the global pharmaceutical market reached $940 billion. In monetary terms it grew by 6%. In the future the sector is expected to grow at no less than 3% to 4% a year and if this happens the global pharmaceutical market is expected to reach $1.1 trillion by 2015 and will reach $1.2 trillion in 2016 and up to $1.5 trillion by 2020. The global demographic, epidemiological and economic changes are transforming the pharmaceutical market. The world population is growing rapidly and is projected to raise from 7 billion in 2011 to 7.7 billion in 2020 and 9.6 billion in 2050, hence an increase in the demand for pharmaceuticals.
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This page was last updated on 10th Sep, 2015