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Hookworm vaccine Hookworm infection is a parasitic nematode that lives in the small intestine caused by the soil-transmitted nematodes Ancylostoma duodenale and Necator americanus is one of the most common parasitic infections in sub-tropical and tropical climates of Latin America, Africa, Asia and worldwide. it causes significant morbidity in the form of anemia, intestinal blood loss, as well as iron and protein malnutrition. Current global control efforts based on periodic mass anthelmintic administration are unsustainable, and new control strategies must be developed. Therefore, a prophylactic vaccine against hookworm infection would provide an attractive additional tool for the public-health control of this disease. This review describes progress in the development of vaccines against hookworm infection, including the preclinical and initial clinical testing of the N. americanus Ancylostoma Secreted Protein-2 Hookworm Vaccine. An eventual hookworm vaccine will most likely be integrated into existing control programs that currently target children living in areas of high transmission, although because of the burden of disease in pregnant women and older individuals, these populations may also be targeted. By simultaneously targeting two enzymes in the blood digestion and detoxification pathway, we hypothesize that the bivalent human hookworm vaccine will elicit neutralizing antibodies that will have a substantial impact on host worm burden (as measured by quantitative fecal egg counts) and blood loss. It is anticipated that vaccination with both recombinant proteins will be needed to disrupt this complex system of hemoglobin digestion, and thereby reduce parasite fecundity and survival at a more rapid rate. Based on previous animal trials conducted during preclinical efficacy testing of each antigen individually, thereby ensuring that any newly licensed hookworm vaccine is rapidly made available.More
OMICS International Organizes 1000+ Global Events Every Year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 700+ Open access journals which contains over 100000 eminent personalities, reputed scientists as editorial board and organizing committee members. The conference series website will provide you list and details about the conference organize worldwide.
Hookworm vaccine Hookworm infection is a parasitic nematode that lives in the small intestine caused by the soil-transmitted nematodes Ancylostoma duodenale and Necator americanus is one of the most common parasitic infections in sub-tropical and tropical climates of Latin America, Africa, Asia and worldwide. it causes significant morbidity in the form of anemia, intestinal blood loss, as well as iron and protein malnutrition.More
World Vaccine Congress 29-31 March 2016, USA
9th vaccine and ISV congress 18-20 Oct 2015 Seoul, South Korea
World Vaccine Congress Asia 2016 Singapore
Annual Conference on Vaccine Research April 18-20 2016 Baltimore USA
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This page was last updated on 11th Sep, 2015
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