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Erythrosomes are specially engineered vesicular systems in which chemically cross-linked human erythrocyte cytoskeleton are used as a support on which a lipid bilayer is coated. Erythrosomes can be achieved by modified procedure normally adopted for reverse phase evaporation. Erythrosomes are proposed as useful encapsulation system particularly for macromolecular drugs. Large (3, tm diameter) mechanically stable proteoliposomes (erythrosomes) were prepared in good yield by coating cross linked erythrocyte cytoskeletons with phosphatidyl choline. Pentamidine primaquine phosphate and metronidazole have been successfully utilized erythrosomes for the treatment of leshmaniasis, malaria on experimental a models. It can be serves as ideal carrier for antineoplastic drugs like bleomycin. Vitamin and steroid have been encapsulated in RBCs. It serves as a cellular sustain delivery system for in vivo administration of recombinant erythropoietin. RBCs coated with recombinant interlukinare reported to provide sustain release to allow low and non-toxic concentration of rlL-2 in circulation. Erythrocyte, which is also known as red blood cells, has been extensively studied by scientists for their capability as a potential carrier for the delivery of drugs and drug-loaded microspheres.
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Scope and Importance:
The use of erythrosomes looks promising for a safe and sure delivery of various drugs for passive and active targeting. However, the concept needs further optimization to become a routine drug delivery system. The same concept also can be extended to the delivery of biopharmaceuticals, Proteins, steroids. erythrosomes are used for targeting drug delivery system depending on sustain release insulin, antiviral agent, Oxygen deficiency therapy etc. was found to be very beneficial to use as a novel drug delivery system.
Erythrosomes, as a drug delivery system has excellent capacity to enhance the therapeutic index and patient compliance. It has got tremendous potential to achieve site specific drug delivery with least wastage of drugs and it also prolong the release of drug. For the preparation of such drug-loaded carrier erythrocytes, the blood samples are simply collected from the organism of interest, and then the erythrocytes are separated from plasma. The drug is entrapped in the erythrocytes, and resealing the resultant cellular carriers. Erythrocytes are biocompatible, biodegradable and the most important advantages are that it possesses long circulation half-lives. It can be easily prepared by simple technique and can be loaded along with a variety of biologically active compounds.
According to IMS Health Consulting, an international research company, in 2012 the size of the global pharmaceutical market reached $940 billion. In monetary terms it grew by 6%. In the future the sector is expected to grow at no less than 3% to 4% a year and if this happens the global pharmaceutical market is expected to reach $1.1 trillion by 2015 and will reach $1.2 trillion in 2016 and up to $1.5 trillion by 2020. The global demographic, epidemiological and economic changes are transforming the pharmaceutical market. The world population is growing rapidly and is projected to raise from 7 billion in 2011 to 7.7 billion in 2020 and 9.6 billion in 2050, hence an increase in the demand for pharmaceuticals.
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This page was last updated on 10th Sep, 2015
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