ADME testing

ADME is a sort of in the pharmacokinetics for absorption of the drug, distribution into the tissues, metabolism, and elimination of the drug from the body, which explains the disposition of a pharmaceutical compound within an organism. All these influences the concentration levels of the drug and its absorption to the tissues and therefore manipulates the performance and pharmacological activity of the molecule as a drug.

Absorption
A drug is absorbed into the tissue through a blood stream via digestive track, etc and reaches the target cells. It significantly describes the compound's bioavailability. Intravenous and inhalation routes of administration will be taken only if the drugs are absorbed poorly when administered orally. Routes of administration are an important consideration.

Distribution
Distribution is the transport of a drug between one part of the body to another. The drug is carried to its target site mostly through the bloodstream and distributed into muscle and organs. The drug is then administered to numerous distribution processes, after entering into the systemic circulation, either by injection or by absorption from any of the various extracellular sites.

Metabolism
The drug is metabolised as soon as it enters the body. During metabolism, the parent drug is converted to new molecules or compounds known as metabolites. These secondary metabolites may be pharmacologically active, occasionally more than the parent drug.

Excretion
After the pharmacological effect of the drug, the drug and its metabolites need to be eliminated from the body through excretion in the form of urine or in the form of feces. If the excretion is not done, the metabolites may adversely affect normal metabolism of the organism.

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Conferences on ADME:
7th annual ADME & Predictive Toxicology Congress
9th annual ADMET Conference
10thAnnual International Conference on Predictive Human Toxicity and ADME/Tox Studies
ADME 2015 Annual Conference
ADME, PK/TK, and Drug Metabolism in Drug Discovery and Development

ADME Associations:
National Institute of Health
PK/PD association
FDA
WHO

This page will be updated regularly.

This page was last updated on April 20, 2024