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Protein Kinase


As per available reports about 39 relevant journals, 171 Conference Proceedings, 11 conferences are presently dedicated exclusively to protein kinase.

Protein Kinases modifies other proteins by chemically adding phosphate groups to them (phosphorylation). Phosphorylation usually results in a functional change of the target protein (substrate) by changing enzyme activity, cellular location, or association with other proteins. They are key regulators of cell function that constitute one of the largest and most functionally diverse gene families. The human genome contains about 500 protein kinase genes and they constitute about 2% of all human genes. By adding phosphate groups to substrate proteins, they direct the activity, localization and overall function of many proteins, and serve to orchestrate the activity of almost all cellular processes.

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Scope and Importance

Kinases are particularly prominent in signal transduction and co-ordination of complex functions such as the cell cycle. The diversity of essential functions mediated by kinases is shown by the conservation of some 50 distinct kinase families between yeast, invertebrate and mammalian kinomes. These can be clustered into groups, families and sub-families, of increasing sequence similarity and biochemical function. Most kinases act on both serine and threonine (serine/threonine kinases), others act on tyrosine, and a number act on all three. The kinase dendrograms show the sequence similarity between these catalytic domains: the distance along the branches between two kinases is proportional to the divergence between their sequences.

Market Analysis

Protein crystallization is the most crucial and the largest segment, and it accounted for 47% of the market in 2013. On the basis of products, the protein crystallization market has segments such as reagents/consumables and instruments. Reagents/consumables accounted for 85% of the protein crystallization & crystallography product market. It is expected to grow at a high CAGR of 11% over the forecast period. The global market was valued at $775 million in 2013 and is expected to reach $1,253 million by 2018.

Seven major groups are labeled and colored distinctly. For instance, the tyrosine kinases form a distinct group, whose members phosphorylate proteins on tyrosine residues, whereas enzymes in all other groups phosphorylate primarily serine and threonine residues. Most kinases act on both serine and threonine, others act on tyrosine, and a number act on all three. The relationships shown on the tree can in some instances be used to predict protein substrates and biological function for many of the over 100 uncharacterized kinases presented here. A further 40 ‘atypical’ kinases have no sequence similarity to typical kinases, but are known or predicted to have enzymatic activity, and some are predicted to have a similar structural fold to typical kinases.

List of Best International Conferences

1. Nuclic Acids Conference
    Aug 4-6, 2016 Seattle, USA

2. Synthetic Biology Conference
   September 28-30, 2015 Houston, USA

3. Protein Engineering Conference
    October 26-28, 2015 Chicago, USA

4. Clinical And Molecular Genetics Conference
    November 28-30, 2016 Chicago, USA

5. 2nd Transcriptomics Conference
    August 15-17, 2016 Portland, USA

6. 3rd Genomics & Pharmacogenomics Conference
    September 21-23, 2015 San Antonio, USA

7. 3rd Clinical Pharmacy Conference
    December 07-09, 2015 Atlanta, USA

8. 4th Integrative Biology Conference
    June 13-15, 2016 Berlin, Germany

9. 4th Clinical Microbiology and Microbial Genomics Conference
   October 05-07, 2015 Philadelphia, USA

10. 5th Computational Systems Biology Conference
      August 22-23, 2016 Philadelphia, USA

11. 5th Metabolomics Conference
     May 16-18, 2016 Osaka, Japan

12. 6th Metabolomics Conference
      November 28-30, 2016 Florida, USA

13. 6th Proteomics  Conference
      March 29-30, 2016 Atlanta, USA

14. 6th Bioinformatics Conference
      March 29-30, 2016 Valencia, Spain

15. 7th Proteomics  Conference
       October 10-12, 2016 Rome, Italy

16. EMBO Practical Course to Targeted proteomics: Experimental design and data analysis
      September 28 to October 03, 2014 Barcelona, Spain

17. HUPO 2015 to HUPO 14th Annual World Congress
      Septemebr 26-30, 2015 Vancouver, Canada


Related Societies and Associations

1. American Society for mass Spectrometry

2. Austrian Proteomics Society

3. American Electrophoresis Society

4. British Mass Spectrometry Society

5. California Separation Science Society

6. Canadian Mass Spectrometry Society

7. Danish Mass Spectrometry Society

8. European Proteomics Association

9. US Human Proteome Organization

10. Proteomics and Electrophoresis Societies

11. Spanish Proteomics Society– (Seprot)

12. Netherlands Proteomic Platform (Npp)

13. Japan Human Proteome Organisation (Jhupo)

14. Italian Proteomic Association (Itpa)

15. Portugese Proteomic Association (Rede Procura)

16. Iranian Proteomic Society

17. Taiwan Proteomic Society (Tps)

18. Human Proteome Organization

19. Italian Proteomics Association

20. Portuguese Proteomics Association


Related Companies

1. Caprion Proteomics

2. Applied Proteomics, Inc.

3. Proxeon

4. PTM Biolabs Inc

5. Biotech Support Group

6. BiognoSYS AG

7. GeneCopoeia

8. Sera Proteomics

9. Protein Metrics Inc.

10. MRM Proteomics Inc.

11. Agilent Technologies

12. Danaher

13. Thermo Fischer Scientific

14. Ab Sciex

15. Abbott Laboratories

16. Affymetrix

17. Ams Biotechnology

18. Avacta Life Sciences

19. Bd Biosciences

20. Biocompare

This page will be updated regularly.

This page was last updated on 11th Sep, 2015

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