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Pharmacometabolomics also known as pharmacometabonomics, is a field which stems from metabolomics, the quantification and analysis of metabolites produced by the body. It refers to the direct measurement of metabolites in an individual’s bodily fluids, in order to predict or evaluate the metabolism of pharmaceutical compounds, and to better understand the pharmacokinetic profile of a drug. Pharmacometabolomics complements the omics with direct measurement of the products of all of these reactions, but with perhaps a relatively smaller number of members: that was initially projected to be approximately 2200 metabolites, but could be a larger number when gut derived metabolites and xenobiotics are added to the list. The application of metabolomics for the study of drug effects and variation in drug response is creating "pharmacometabolomics," a discipline that will contribute to personalized drug therapy and will complement pharmacogenomics by capturing environmental and microbiome-level influences on response to drug therapy.
Pharmacometabolomics analyses, through the use of a metabolomics approach, can provide a comprehensive and detailed metabolic profile or “metabolic fingerprint†for an individual patient. Such metabolic profiles can provide a complete overview of individual metabolite or pathway alterations, providing a more realistic depiction of disease phenotypes. This approach can then be applied to the prediction of response to a pharmaceutical compound by patients with a particular metabolic profile.
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Pharmacometabolomics Conferences in 2015:
• Metabolomics 2015, San Francisco, California
• Plant Metabolomics Session at the ASBM Annual Meeting, Boston, Massachusetts,2015
• 2nd Australian Lipid Meeting, Wollongong, NSW, Australia
• ICMSB 2015 : XIII International Conference on Metabolomics and Systems Biology, Paris
• Systems Biology of Lipid Metabolism 2015, Breckenridge, USA
• International Conference on Systems Biology and Bioengineering (ICSBB 2015),Turkey
• Metabolomics and Epidemiology Symposium at RTI International, NC USA
Lists of Societies related to Pharmacometabolomics :
• The Metabolomics Society,US
• COSMOS - COordination of Standards in Metabolomics ,UK
• Northwest Metabolomics Research Center (NW-MRC), Seattle,US
• Swedish Metabolomics Centre, Sweden
• Netherlands Metabolomics Centre.
• The International Society for Systems Biology (ISSB)
• PRiMe Platform for Riken Metabolomics
Major Pharmacometabolomics and related Companies:
• AB SCIEX, USA
• Metabolomic Diagnostics Ltd, Ireland
• Chenomx ,Canada
• Phenomenome Discoveries, Canada
• Metabometrix , London
• Metabolon, USA
• Lipomics, California
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This page was last updated on April 20, 2024