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A mutagen is known as a physical or chemical agent, which can alter the genetic material, commonly DNA. Hence this particular property of the agent is known as mutagenicity. The agent can cause the permanent alterations in the genetic material.
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Scope and Importance:
In 1927 the mutagenic property of mutagens was first demonstrated. Mutagens cause changes to the polymer/DNA which will have an effect on the transcription and replication of the polymer/DNA that in severe cases will cause to the cell death. The agent produces mutations within the polymer, and upsetting mutation may result in aberrant, impaired or loss of perform for a specific factor, and accumulation of mutations could cause cancer. Several mutagens act on the polymer otherwise. Powerful mutagens could lead to body instability, inflicting body breakages and transcription of the chromosomes like translocation, deletion, and inversion. Such mutagens ar known as clastogens.
Mutagens might also alter the DNA sequence; the changes in polymer sequences by mutations embrace substitution of nucleotide base-pairs and insertions and deletions of one or more number of nucleotides in polymer sequences. Though a number of these mutations can cause serious diseases, several have minor results as they are not lead to residue alters that have vital effect on the structure and performance of the proteins. Several mutations are silent mutations, inflicting no visible effects in the least, either as a result of they occur in non-coding or non-functional sequences, or usually they do not modify the amino-acid sequence attributable to the redundancy of codons. Some mutagens will cause aneuploidy and alter the more number of chromosomes within the cell.
Mutagens could be of physical, chemical or biological origin. They will act directly on the polymer, inflicting direct harm to the DNA, and most frequently end in replication error. Some but could act on the replication mechanism and body partition. Several mutagens don't seem to be mutagenic by themselves; however will form agent metabolites through cellular processes and such mutagens are known as promutagens.
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By 2017 the global market for mutagenicity is estimated to reach US$2.2 . Expanding knowledge in genetic testing is one of the major reasons for the growth of the genetic testing market. The other factors which propel the growth of the genetic market are aging population, rise in the number of chronic diseases , increased risk of cancer etc.
Molecular market diagnosis market is represented by genetic testing and it’s the most rapidly expanding segment worldwide. The transmutation of genetic testing from a service-driven market to a product-driven market is expected to provide an impetus to the diagnostic companies for the expansion of their operations. The market for screening the newborns, diagnosing rare and fatal disorders, and predicting the probability of occurrence of diseases is likely to expand. Genetic tests which are used to screen the newborns are expected to build-up immensely over the coming years.
The highest market globally is represented by the US
Key industries profiled in the report include Abbott Laboratories, Abbott Molecular Inc., Applied Biosystems Inc., AutoGenomics Inc., BioRad Laboratories, Celera Group, ELITech Group, PerkinElmer Inc., Quest Diagnostics Inc., Roche Diagnostics Corp., Roche Molecular Diagnostics Inc., Transgenomic Inc., among others.
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This page was last updated on 15th Sep, 2015
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