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In 1788, Edward Jenner, an English country doctor from Gloucestershire variolation a healthy, 8-year-old boy with cowpox a disease caused by a virus that closely resembles variola (highly contagious viral disease). Cowpox's natural hosts are small mammals such as wood mice, but the virus can spread to other animals, especially cattle like cows. The disease causes lesions an abnormal change in structure of an organ or part due to injury or disease. Especially one that is circumscribed and well defined and the udders and teats that can infect humans who milk them. Edward Jenner, fiduciaries the world's first vaccination as a preventive treatment for smallpox, a disease that had killed millions of people over the centuries. The smallpox vaccine helps the body develop immunity to smallpox. The vaccine is made from a virus contained live vaccinia which is a pox type virus similar to cowpox and closely related to variola. The smallpox vaccine contains the live vaccinia virus not dead virus like many other vaccines. For that reason, the vaccination site must be cared for carefully to prevent the virus from spreading. Also, the vaccine can have side effects. The vaccine does not contain the smallpox virus and cannot give you smallpox. In the 19th and 20th centuries, scientists following Jenner's model developed new vaccines to fight numerous deadly diseases, including polio, whooping cough, measles, tetanus, yellow fever, typhus, and hepatitis B, and many others. More sophisticated smallpox vaccines were also developed and by 1970 international vaccination programs, such as those undertaken by the World Health Organization, had eliminated smallpox worldwide. Smallpox vaccine that was used in the United States until 1972, when smallpox vaccinations were stopped, vaccinia virus a highly contagious viral disease virus. Before 1972, most young children were vaccinated against smallpox, as were military recruits and many people traveling to other countries. While still a medical student, Jenner noticed that milkmaids who had contracted a disease called cowpox, which caused blistering on cow's udders, did not catch smallpox. Unlike smallpox, which caused severe skin eruptions and dangerous fevers in humans, cowpox led to few ill symptoms in these women. On May 14, 1796, Jenner took fluid from a cowpox blister and scratched it into the skin of James Phipps, an eight-year-old boy. A single blister rose up on the spot, but James soon recovered. On July 1, Jenner inoculated the boy again, this time with smallpox matter, and no disease developed. The vaccine was a success.more
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The smallpox vaccine helps the body develop immunity to smallpox. The vaccine is made from a virus called vaccinia which is a “pox”-type virus related to smallpox. The smallpox vaccine contains the “live” vaccinia virus—not dead virus like many other vaccines. For that reason, the vaccination site must be cared for carefully to prevent the virus from spreading.
Market analysis : In the past 5 years, Bavarian Nordic has delivered 28 million smallpox vaccine doses to the U.S. government's stockpile to protect against renegade stocks or re-engineered viruses. Global revenue for small pox vaccine was nearly $31.8 billion in 2011.This market is expected for small pox vaccine to increase from $65.6 billion in 2020. In the case of USA $11.3billion in 2011 ,but it will increase half of the percentage by the end of 2017. Geographically,south America, dominates the market followed by Europe. South America accounted for about ~38% share in the small pox vaccine market in 2013 owing to the heavy investments by multinational companies in research and development of vaccine . On the other hand, Asia-Pacific market would grow at the promising CAGR of 8.7% during the forecast period.
World Vaccine Congress 29-31 March 2016, USA
9th vaccine and ISV congress 18-20 Oct 2015 Seoul, South Korea
World Vaccine Congress Asia 2016 Singapore
Annual Conference on Vaccine Research April 18-20 2016 Baltimore USA
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This page was last updated on 11th Sep, 2015
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