Open Symposium
 Tuesday, January 19, 2010
 Bechtel Conference Center at Encina Hall
 616 Serra Street
 Stanford, CA 94305-6055

7:30 –8:00 am Refreshments
8:00–8:15 am Welcome (Beverly Mitchell, MD., Stanford Univ.
                  Sudhir Srivastava, Ph.D., M.P.H., NCI)
8:15–8:30 am Introduction to the NCI Glycomics Alliance
Karl Krueger, Ph.D. - NCI
8:30–9:00 am Title: Normal and Neoplastic Stem Cells
Irving Weissman, M.D., Ph.D., Director, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford Univ.
9:00–9:30 am Title:The Role of Galectin-3 and Related Molecules in the Diagnosis and Therapy of Epithelial Neoplasia
Robert Bresalier, M.D., Univ. of Texas MD Anderson Cancer Center
9:30–10:00 am Title: Glycans and their Role in Regulating Immunity
John Lowe, M.D., Genentech
10:00–10:30 am Title: Heparan Sulfate Endosulfatases and Cancer
Steve Rosen, Ph.D., Univ. Of Califonia San Francisco
10:30–10:45 am Break
10:45–11:15 am Title: O-glycans and Glycan-binding Proteins Associated with Tumorigenesis and Disease Progression
Rick Cummings, Ph.D., Emory Univ.
11:15–11:45 pm Title: Development of a Longitudinal CA125 Algorithm as a Component of a Screening Method for Early Detection of Ovarian Cancer
Steven Skates, Ph.D., Massachusetts General Hospital
11:45–12:15 pm Title: Molecular Imag(in)ing
Sanjiv Sam Gambhir, M.D., Ph.D., Stanford Univ.
12:15–1:15 pm Lunch

Overview of Activities in the Alliance of Glycobiologists for Detection of Cancer and Cancer Risk
1:15 –1:40 pm Title: Targeting Immunogenic Sugar Moieties of HIV-1 and Human Cancers
Denong Wang, Ph.D., Stanford Univ. & SRI (Jan., 2010)
1:40–2:05 pm Title: Integrating Knowledge from Glycomic and Glycoproteomic Measurements in Cancer Research
Milos Novotny, Ph.D., Indiana Univ.
2:05–2:30 pm Title: The Immune System as a Sensitive Detector of a Novel Tumor Antigen, Arising from Combined Genetic and Dietary Mechanisms
Ajit Varki, M.D., Univ. Of California San Diego
2:30–2:55 pm Title: The Development of Novel Glycoproteomics Technology for Biomarker Discovery in Plasma Proteins and Circulating Tumor Cells
William Hancock, Ph.D., Northeastern Univ.
2:55–3:15 pm Break
3:15–3:40 pm Title: Signatures of Malignant Transformation Defined by Anti-Glycan Antibodies
Margaret Huflejt, Ph.D., New York Univ.
3:40–4:05 pm Title: Early Detection of Pancreatic Cancer: Autoantibodies and Mucin Glycoprotein Antigens
Michael Hollingsworth, Ph.D., Univ. of Nebraska
4:05–4:30 pm Title: Oncogenically Altered Glycan Expression Drives Cancer Marker Discovery
J. Michael Pierce, Ph.D., Univ. of Georgia
4:30–5:30 pm Panel Discussion
5:30 pm Adjourn

Closed Meeting between the Alliance and the Advisors
Wednesday, January 20, 2010

Stanford Park Hotel, Menlo Room
100 El Camino Real, Menlo Park, CA 94025
8:00–8:30 am Refreshments
8:30–10:15 am Discussion Concerning Progress of the Alliance
10:15–10:30 am Break
10:30–12:00 pm Discussion on Future Directions for Glycomic Cancer Research in Diagnostics
12:00 pm Adjourn