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As per available reports about 43 relevant Journals, 38 Conferences are presently dedicated exclusively to Xenotransplantation and about 208 articles are being published on Xenotransplantation .
Xenotransplantation is the transplantation of living cells, tissues or organs from onespecies to another. Such cells, tissues or organs are called xenografts or xenotransplants. In contrast, the termallotransplantation refers to a same-species transplant. Human xenotransplantation offers a potential treatment for end-stage organ failure, a significant health problem in parts of the industrialized world. It also raises many novel medical, legal and ethical issues. A continuing concern is that many animals, such as pigs, have a shorter lifespan than humans, meaning that their tissues age at a quicker rate. Disease transmission and permanent alteration to the genetic code of animals are also causes for concern. A few successful cases of xenotransplantation are published. Pharmacological and Toxicological Sciences is wide range of biological science including subtopics Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoepidemiology, Clinical pharmacology, Immunology¸ and Cardiovascular pharmacology.
Organ transplantation is one of the success stories of the second half of the twentieth century. Indeed, it is its very success, resulting in the referral of ever-increasing numbers of patients that has generated a crisis in donor organ our improved understanding of the immune system and the immune rejection process has resulted in developing therapies that hopefully will overcome the vigorous immune responses associated with the transplantation of xenogeneic tissues. It appears likely that, during the next few years, human clinical trials utilizing animal cells and organs to treat some of these diseases will become a reality.
Xenotransplantation is the transplantation of living cells, tissues or organs from onespecies to another. Such cells, tissues or organs are called xenografts or xenotransplants. In contrast, the termallotransplantation refers to a same-species transplant. Human xenotransplantation offers a potential treatment for end-stage organ failure, a significant health problem in parts of the industrialized world. It also raises many novel medical, legal and ethical issues. A continuing concern is that many animals, such as pigs, have a shorter lifespan than humans, meaning that their tissues age at a quicker rate. Disease transmission and permanent alteration to the genetic code of animals are also causes for concern. A few successful cases of xenotransplantation are published.
Organ transplantation, using human donor organs, as a form of surgical therapy began in the middle of the twentieth century, when Joseph Murray and his colleagues performed the first truly successful renal transplant between identical twins in Boston. This success was subsequently extended to transplantation of kidneys from more distantly related and unrelated donors through the use of immunosuppressive drugs such as azathioprine and glucocorticoids and, more recently, ciclosporin and tacrolimus. To date, it is estimated that close to 500000 patients worldwide have received life-sustaining renal transplants.
The medical applications of transplantation technology have grown significantly during the past few decades to include heart, lung, liver, pancreas and intestine transplantation. Although most attention has been directed towards transplantation of whole organs and bone marrow stem cells, isolation and transplantation of cells and tissues with specific differentiated functions (e.g. pancreatic islets, which secrete insulin) represents an important conceptual and technological advance.
Market Analysis:
The global market for organ and tissue transplantation products and devices reached $56.9 billion in 2014. This market is estimated to grow at a compound annual growth rate (CAGR) of 7.1% to reach $64.4 billion by 2015 and nearly $90.6 billion by 2020. Detailed examination of procurement and preservation, solid organ transplantation, tissue transplantation, immunosuppressives and other pharmaceuticals, post-transplantation concerns, as well as alternatives to transplantation.
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This page was last updated on April 19, 2024