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As per available reports about 7 relevant Journals, 5 Conferences, 87 Workshops are presently dedicated exclusively to Transcriptional attenuation and about 164 articles are being published on Transcriptional Attenuation.
Transcriptional Attenuation genetically is a proposed mechanism of control in some bacterial operons which a result in premature termination of transcription and which is based on the fact that, in bacteria, transcription and translation proceed simultaneously. Attenuation involves a provisional stop signal (attenuator), located in the DNA segment that corresponds to the leader sequence of mRNA. During attenuation, the ribosome becomes stalled (delayed) in the attenuator region in the mRNA leader. Depending on the metabolic conditions, the attenuator either stops transcription at that point or allows read-through to the structural gene part of the mRNA and synthesis of the appropriate protein.
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Scope and Importance:
Transcriptional Attenuation conferences are based on the latest research going on the mechanism of Transcription and its regulatory feature found throughout Archaea and Bacteria causing premature termination of transcription. Attenuators are 5'-cis acting regulatory regions which fold into one of two alternative RNA structures which determine the success of transcription. The folding is modulated by a sensing mechanism producing either a Rho-independent terminator, resulting in interrupted transcription and a non-functional RNA product; or an anti-terminator structure, resulting in a functional RNA transcript. There are now many equivalent examples where the translation, not transcription, is terminated by sequestering the Shine-Dalgarno sequence (ribosomal binding site) in a hairpin-loop structure. While not meeting the previous definition of (transcriptional) attenuation, these are now considered to be variants of the same phenomena and are included in this article. Attenuation is an ancient regulatory system, prevalent in many bacterial species providing fast and sensitive regulation of gene operons and is commonly used to repress genes in the presence of their own product (or a downstream metabolite).
The global transcriptomics market was valued at $1,743.2 in 2013. This market is expected to reach $3,773.0 million by 2019 at a CAGR of 13.7% from 2014 to 2019. In this report, the global transcriptomics market is segmented as by technology, by applications, and by end-users. Market by technology comprises of microarray, PCR, sequencing, and RNAi gene silencing technologies whereas, the market by applications include clinical diagnostics, drug discovery, and toxicogenomics. The market by end-users includes pharmaceutical and biotechnology companies, academic research and government institutes, and hospitals and diagnostic centers.
The transcriptomics market has witnessed significant growth in the past few years mainly due to the increasing technological advancements in the field of ‘omics’ research and application of sequencing technologies in RNA Analysis research. Similarly, the increasing government and private funding for research coupled with research and development investments by the biotechnology companies are expected to drive the transcriptomics market. Similarly, the application of RNA Analysis in the field of biomarker discovery opens new growth avenues with the rising preference of personalized medicine across the globe. However, the higher investment costs that restrict the adoption of RNA Analysis products and dearth of skilled professionals are the factors hampering the growth of this market to a certain extent.
The RNA Analysis technologies market comprises of microarray, PCR, sequencing including Sanger sequencing and NGS, and RNAi gene silencing. Each of these technologies are further segmented into reagents, instruments, and software. PCR technology has dominated the market due to its increasing application in RNA sequencing.. However, the sequencing segment including NGS is expected to grow at a higher CAGR due the increase in read lengths facilitated by this technology, reduced costs, and faster sequencing from existing platforms.
North America holds the largest share of the global transcriptomics market. However, in the forthcoming years, developing regions such as Asia-Pacific (Japan, China, and India) and Latin America are expected to form new revenue-generating pockets for the market players. Economic developments and growing government funding to support new product developments are the key factors driving the growth of market in developing regions.
The market is dominated by players such as Affymetrix Inc. (U.S.), Agilent Technologies Inc. (U.S.), Bio-Rad Laboratories Inc. (U.S.), GE Healthcare (U.S.), Illumina Inc. (U.S.), Qiagen N.V. (Germany), F. Hoffmann-La Roche Ltd. (Switzerland), Sigma Aldrich (U.S.), Fluidigm Corporation (U.S.) and Thermofisher Scientific Inc. (U.S.).
1. Genetic Counselling and Genomic Medicine Conference
August 11-12, 2016 Birmingham, UK
2. Molecular & Cancer Biomarkers Conference and Expo
September 15-17, 2016 Berlin, Germany
3. Clinical and Molecular Genetics Conference
November 28-30, 2016 Chicago, USA
4. 5th Cell and Gene Therapy Conference
May 19-21, 2016 San Antonio, USA
5. 2nd Transcriptomics Conference
August 18-20, 2016 Portland, Oregon USA
6. 6th Bioinformatics Conference
March 29-30, 2016 Valencia, Spain
7. 6th Proteomics Conference & Expo
March 31-Apr 2, 2016, Atlanta, USA
8. 5th Metabolomics Conferences
May 16-18, 2016, Osaka, Japan
9. Structural Biology Conference
June 23-24, 2016, New Orleans, USA
10. Next Generation Sequencing Conference
July 21-22, 2016, Berlin, Germany
11. Nucleic Acids Conference
Aug 4-6, 2016, Seattle, USA
12. Biochemistry Conference
Oct 13-15, 2016, Kuala Lumpur, Malaysia
13. 7th Proteomics Conference and Expo
Oct 24-26, 2016, Rome, Italy
14. 7th Bioinformatics Conference
Oct 27-28, 2016, Chicago, USA
15. 2nd Genetic and Protein Engineering Conference
Nov 14-16, 2016, Atlanta, USA
16. 6th Metabolomics Conference
Nov 28- 30, 2016, Chicago, USA
17. Glycomics Conference
Dec 1-3, 2016, Chicago, USA
19. Metabolism, Transcription and Disease, Utah, USA
20. Transcription and Chromatin, Heidelberg, Germany
21. Noncoding RNAs in Health and Disease, New Mexico, USA
22. The RNA Society's Meeting, Quebec, Canada.
23. Noncoding RNAs and Cancer, Boston, USA
24. Non-Coding Genome, Heidelberg, Germany
25. Non-coding RNAs and RNAP II Regulation in Development and Disease, Texas, USA
Relevant Societies and Associations:
1. The Association of Bimolecular Resource Facilities (ABRF), Bethesda, MD, USA
2. American Society of Gene and Cell Therapy, Milwaukee, Wisconsin, USA
3. Triangle Chromatography Discussion Group, USA
4. American Chemical Society
5. American Society for Microbiology, USA
6. RNA Society - Maryland, USA
7. University of Nebraska Medical Centre, Omaha, Nebraska, USA
8. US HUPO, Santa Fe, New Mexico, USA
9. The Protein Society, USA
10. Society for Industrial Microbiology and Biotechnology, Fairfax, Virginia, USA
11. Federation of American Societies for Experimental Biology (FASEB), Maryland, USA
12. BioFlorida- Life Science Community
13. European Society of Human Genetics, Vienna, Austria
14. European Proteimcs Association (EuPA), UK
15. British Society for Proteome Research (BSPR), UK
16. Swiss Proteomics Society (SPS), Switzerland
17. Proteomics Society, India
1. Affymetrix - Santa Clara, California USA
2. Roche NimbleGen Inc. Madison, Wisconsin, United States
3. SciGene Sunnyvale, California, United States
4. Arrayit Corporation
5. DNAmicroarray California, USA
6. LC Sciences, Houston, TX, US
7. SeqWright Genomic Services (a unit of GE health care)
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This page was last updated on 17th Sep, 2015
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