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ANANBIOANAL - 2010
Pharmaceutical R & D Summit
doi:10.4172/2155-9872.1000055
Intersection of Biophysical Studies and Drug Design. Use of the
“Efficiency Coefficient” and “Drug Design Matrix”
Michael Shapiro
University of Maryland School of Pharmacy, Baltimore, USA
A
s we all know, the NCE that reach market have been dwindling even though our
ability to use technology has increased. This might be due to the fact that all the
easy targets are well studied and only the intractable systems are being investigated
and/or; this means we must be doing something fundamentally incorrect. In the
seminar today, I will present the basis of fragment based drug design and some of
the tools that can be used to evaluate what to do next. In addition I will discuss the
limitations of some of tools in understanding molecular recognition and perhaps
what we can do about this situation. I will also talk about some of our results using
NMR spectroscopy, which unfortunately has fallen out of favor recently in the drug
discovery process, showing how it can aid the understanding of the molecular
recognition process by providing us information not easily attainable by any other
method.
ANALBIOANAL-2010
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