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ANANBIOANAL - 2010
Pharmaceutical R & D Summit
doi:10.4172/2155-9872.1000037
Folate Conjugated INPs from Goat Blood for Cellular Imaging and
Targeted Delivery for Breast Cancer Cell Lines
T. P. Sastry
Bio-products Lab, Central Leather Research Institute, Adyar, Chennai, India
I
n the present article, we report the preparation of iron nanoparticles (INPs) from
goat blood and fabrication of a biocomposite by coating these nanoparticles with
chitosan coupled with folic acid (INP-CF). This biocomposite was characterized for
its physicochemical properties and cancer cell targeting studies. The size of the
INP-CF was found to be 80-300nm. FT-IR studies have confirmed the presence of
chitosan and folic acid (F) in the composite. Cancer cell line studies confirmed the
internalization of INP-CF and this phenomenon was also supported by SEM-EDX
and MRI analyses. The cell viability was found to be 71.5% as determined by the
MTT assay.
ANALBIOANAL-2010
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