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ANANBIOANAL - 2010
Pharmaceutical R & D Summit
doi:10.4172/2155-9872.1000025
Antibacterial Metallopharmaceuticals: Into the Nanoscale Regime
of Silver
Joon Myong Song
College of Pharmacy, Seoul National University, Seoul, South Korea
B
acterial resistance towards to common antibiotics, results development of
antibacterial metallopharmaceuticals (silver nanoparticles) (AgNP). AgNPs of
different shapes were synthesized by solution phase routes, and their interactions
with E.coli were studied. The antibacterial activity of silver compounds loaded on
porous host matrices are evaluated under short contact time where in the bacterial
load was exposed not directly to the metal-loaded material but to distilled water
pretreated with them, was mainly attributed to generation of reactive oxygen
species (ROS). In this work we first investigated the shape dependence of the
antibacterial activity of silver nanoparticles. We also developed highly antibacterial
porous carbon matrices supporting nano-silver by simple and cost effective way.
EFTEM micrographs of the bacterial cells showed considerable changes in the cell
membranes upon AgNP-treatment.
Truncated triangular silver nanoplates with a {111} lattice plane as the basal
plane displayed the strongest biocidal action compared with spherical, rod shaped
nanoparticles or with silver ions. Nanocrystalline silver-supported carbon compos-
ite was fabricated by directly loading AgNPs into the porous host matrix from a
preformed nanosilver hydrosol. The method eliminates the high temperature de-
composition step, thereby minimizing the possibilities of formation of larger silver
particles. XRD calculation indicated the presence of Ag crystallites in nanometer
range; silver nanoparticle hydrosol-treated composite having the finest crystallite
size (<14.4 nm). Ag crystals coalesced significantly with increasing temperature
resulting in much larger particle size in thermally impregnated silver-carbon com-
posites. The results demonstrate for the first time that silver nanoparticles undergo
a shape dependent interaction with bacteria.
ANALBIOANAL-2010
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