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ANANBIOANAL - 2010
Pharmaceutical R & D Summit
doi:10.4172/2155-9872.1000098
Analytical Strategies Employed for Doping Analysis in XIX
Commonwealth Games-2010, in India
Alka Beotra
National Dope Testing Laboratory, Ministry of Youth Affairs and Sports, New Delhi, India
T
he control of drug abuse in athletes has become a highly specialized complex task
which requires use of sophisticated testing procedures. Doping control analysis
using instrumental analytical tools have been performed since the 1960s when
various measures were initiated to control the misuse of performance-enhancing
drugs in sports. Each major game viz. Olympics, Asian games and Commonwealth
Games sees enormous advances in doping control. The analytical strategies
employed for the XIX Commonwealth games testing in India is in compliance with the
WADA ‘prohibited list’ which includes hundreds of substances, ranging from volatile
stimulants to modified polysaccharides and glycoproteins. Apart from prohibited
substances, there are few methods which are also prohibited viz. blood transfusion
and other forms of blood doping. The determination of low molecular weight (700-800
Da) substances (stimulants, narcotics, anabolic agents, glucocorticosteroids, beta-
2-agonists, beta blockers, diuretics, antiestrogens, cannabinoids) was performed
mainly by chromatographic- mass spectrometric technique which is considered
as the gold standard for antidoping analysis. The protein chemistry and molecular
biology components (EPO, CERA, Blood transfusion, Human Growth Hormone) are
analyzed by dedicated analytical techniques for the identification of high molecular
masses viz. electrophoresis, luminometry etc. The presentation will focus on the
various analytical strategies employed in the testing of the mega event so as to set
a milestone of excellence in the field of doping control.
ANALBIOANAL-2010
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