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ANANBIOANAL - 2010
Biomarkers in Cancer: Recent Advances
Sarasija Suresh
Department of Pharmaceutics, Al- Ameen College of Pharmacy, India
Pharmaceutical R & D Summit
doi:10.4172/2155-9872.1000011
B
iomarkers are invaluable tools for cancer detection, diagnosis, patient prognosis
and selection of treatment. In cancer research and treatment, assay of biomarker
can be used to identify the presence of tumour, determine its stage, subtype and
ability to respond to treatment. Further, biomarkers in cancer can be used to better
understand tumour formation and to develop new therapeutic approaches. Despite
years of intensive analysis only a small number of plasma proteins have been validated
as cancer biomarkers such as prostate specific antigen and cancer antigen125. Now
with technological advances in gene expression, genomic and proteomic analysis
discovery of biomarkers is a fast growing area of cancer research. Development of
genomics and proteomics has made it possible to monitor a large number of cellular
pathways simultaneously. This has enabled the identification of biomarkers and
signalling molecules associated with cell growth, cell death and cellular metabolism.
Further, they are facilitating in monitoring the functional disturbances, molecular
and cellular damage and damage response. This talk aims to describe some of
the development of biomarkers in cancer research and detection with emphasis on
different genomic and proteomic tools for the identification and discovery of new
biomarkers including gene expression signatures associated with cancer cells which
can tell us about cancer pathogenesis, progression and help in identifying patients
who are most likely to respond to treatment and ‘single cell proteomics’ to further
understand tumorigenesis and work towards personalized treatment strategies.
ANALBIOANAL-2010
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