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Proniosomes are dry formulations of surfactant coated carrier, which can be measured out as needed and rehydrated by brief agitation in hot water. Stability of dry proniosomes is expected to be more stable than a pre-manufactured niosomal formulation. In release studies proniosomes appear to be equivalent to conventional niosomes. Size distributions of proniosome-derived niosomes are somewhat better than those of conventional niosomes so the release performance in more critical cases turns out to be superior. Proniosomes are dry powder, which makes further processing and packaging possible.
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Scope and Importance:
Proniosomes are promising drug carriers for the future with greater physical, chemical stability and potentially scalable for commercial viability. Proniosomal delivery system holds effective delivery for amphiphilic drugs. Due to advantages of nontoxicity & penetration enhancing effect of surfactants & effective modification of drug release, proniosomes has attracted a greater deal of attention for delivery of drugs through transdermal route. Proniosomes in dry form makes the possibility of convenient unit dosing as they further converted into beads, tablets, capsules. The findings of the studies on proniosomes open the door for the future use of different carriers’ materials with biocompatibity and suitability for the preparation of proniosomes. The future experiments would explore the suitability of proniosomes with more drugs having defined drawbacks for improved & effective intended therapy.
Approaches to stabilize niosomal drug delivery system without affecting its properties of merits have resulted in the development of the promising drug carriers, Proniosomes. Proniosomes derived niosomes are superior to conventional niosomes. These proniosomes minimize problems of niosomes physical stability such as aggregation, fusion, leaking and provide additional convenience in transportation, distribution, storage and dosing. Proniosomes are dry formulations using suitable carrier coated with non-ionic surfactants and can be converted into niosomes immediately before use by hydration. Proniosomal gels have been also reported to enhance the topical drug delivery. Proniosomal gels are the formulations, which on in situ hydration with water from the skin are converted into niosomes. These proniosomes derived niosomes are as good as or even better than conventional niosomes. The focus of this review is to bring out different aspects related to proniosomes preparation, characterization, entrapment efficiency, in vitro drug release, applications and merits.
According to IMS Health Consulting, an international research company, in 2012 the size of the global pharmaceutical market reached $940 billion. In monetary terms it grew by 6%. In the future the sector is expected to grow at no less than 3% to 4% a year and if this happens the global pharmaceutical market is expected to reach $1.1 trillion by 2015 and will reach $1.2 trillion in 2016 and up to $1.5 trillion by 2020. The global demographic, epidemiological and economic changes are transforming the pharmaceutical market. The world population is growing rapidly and is projected to raise from 7 billion in 2011 to 7.7 billion in 2020 and 9.6 billion in 2050, hence an increase in the demand for pharmaceuticals.
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