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Drug repurposing is the application of known drugs and compounds to new indications (i.e., new diseases. A huge point of interest of drug repurposing over conventional medication advancement is that since the repositioned medication has officially passed of lethality and different tests, its safety is known and the danger of disappointment for reasons of adverse toxicology are lessened. More than 90% of drug come up short amid improvement, and this is the most huge purpose behind the high expenses of pharmaceutical R&d. Likewise, repurposed drug can sidestep a great part of the early cost and time required to put up a drug for sale to the public. Drug repositioning, Drug repurposing, Drug rescue, Therapeutic Switching are the different wings constituted under Market analysis and Research opportunity which also include other Pharmaceutical research and Marketing is profused in developed countries like USA, Middle East & Asia Pacific,
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Drug repositioning has already passed a significant number of toxicity and other tests, its safety is known and the risk of failure for reasons of adverse toxicology are reduced. More than 90% of drugs fail during development and this is the most significant reason for the high costs of pharmaceutical R&D. In addition, repurposed drugs can bypass much of the early cost and time needed to bring a drug to market. On the other hand drug repositioning faces some challenges itself since the intellectual property issues surrounding the original drug may be complex and from a commercial point of view it may not always make sense to take such a drug to market.
Drug repurposing has been becoming in importance in the last few years as an expanding number of medication advancement and pharmaceutical organizations see their drug pipelines becoming scarce and understand that many previously promising technologies have failed to deliver as advertised.
Utilizing drug repurposing, pharmaceutical organizations have attained a number victories, for instance Pfizer's Viagra in erectile brokenness and Celgene's thalidomide in severe erythema nodosum leprosum. More diminutive organizations, including Ore Pharmaceuticals, Biovista, Numedicus, Melior Discovery and [SOM Biotech] are additionally performing drug repurposing on an orderly premise. These organizations utilize a mixed methodologies incorporating in silico science and in vivo/in vitro experimentation to evaluate a compound and create and affirm theories concerning its utilization for new evidences. e system lymphoproliferative disorder and familial dysautonomia.
A huge point of interest of drug repurposing over conventional medication advancement is that since the repositioned medication has officially passed a noteworthy number of lethality and different tests, its safety is known and the danger of disappointment for reasons of adverse toxicology are lessened. More than 90% of drug come up short amid improvement, and this is the most huge purpose behind the high expenses of pharmaceutical R&d. Likewise, repurposed drug can sidestep a great part of the early cost and time required to put up a drug for sale to the public. Then again drug repurposing confronts a few difficulties itself since the intellectual property issues encompassing the original drug may be perplexing and from a business perspective it may not always make sense to take such a drug to market.
One notable example of drug repurposing is taking the incomplete mu-opioid receptor agonist buprenorphine - which has been prescribed for control of moderate pain for a decades in low doses as Temgesic 200mcg sublingual tablets, Buprenex 300mcg/ml ampoules - and promoting a high-dosage formulation (Subutex 2 mg and 8 mg) for the intrusion and support of heroin and other opioid addictions, which it has demonstrated extremely helpful for, with in excess of 200,000 individuals in the United States alone on buprenorphine maintenance.
Drug repurposing has become a matter of intense interest during the past few years. It is an approach to drug development that calls for reinvestigation of those drugs that did not succeed in advanced clinical trials (for reasons other than safety) for potential use in other therapeutic indications. Pharma Reports focus on drug repositioning in pharmaceutical R&D—the technologies, the companies, the markets, and the strategic business impacts.
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This page was last updated on 11th Sep, 2015
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