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Thin Film Drug Delivery


As per available reports about 43 Relevant Journals, 43 Conferences, 10 National Symposium are presently dedicated exclusively to thin film drug delivery and about 148 articles are being published on thin film drug delivery.

Thin film drug delivery uses a dissolving film or oral drug strip to administer drugs via absorption in the mouth (buccally or sublingually) and/or via the small intestines (enterically). A film is prepared using hydrophilic polymers that rapidly dissolves on the tongue or buccal cavity, delivering the drug to the systemic circulation via dissolution when contact with liquid is made.

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Scope and Importance:

The design of thin film as an oral drug delivery technology offers several advantages over other modes of drug delivery, such as ingestible tablets, chewable tablets, orally dissolving tablets, soft gels, liquids or inhalants. Importance of thin film drug delivery has emerged as an advanced alternative to the traditional tablets, capsules and liquids often associated with prescription and OTC medications. Similar in size, shape and thickness to a postage stamp, thin-film strips are typically designed for oral administration, with the user placing the strip on or under the tongue (sublingual) or along the inside of the cheek (buccal).

Fast-dissolving drug delivery systems were first developed in the late 1970s as an alternative to tablets, capsules, and syrups for pediatric and geriatric patients who experience difficulties swallowing traditional oral solid-dosage forms (1). In response to this need, a variety of orally disintegrating tablet (ODT) formats were commercialized. Most ODT products were formulated to dissolve in less than one minute when exposed to saliva to form a solution that could then be more easily swallowed.
Dissolvable oral thin films (OTFs) evolved over the past few years from the confection and oral care markets in the form of breath strips and became a novel and widely accepted form by consumers for delivering vitamins and personal care products. Companies with experience in the formulation of polymer coatings containing active pharmaceutical ingredients (APIs) for transdermal drug delivery capitalized on the opportunity to transition this technology to OTF formats. Today, OTFs are a proven and accepted technology for the systemic delivery of APIs for over-the-counter (OTC) medications and are in the early- to mid-development stages for prescription drugs.
 
This article provides insight into the functionality and benefits of dissolvable films and reviews the current product landscape and market potential. The authors also explain how thin films are formulated and manufactured, and discuss potential future applications.
 
Functionality and Benefits
 
Pharmaceutical companies and consumers alike have embraced OTFs as a practical and accepted alternative to traditional OTC medicine forms such as liquids, tablets, and capsules. OTFs offer fast, accurate dosing in a safe, efficacious format that is convenient and portable, without the need for water or measuring devices (2). OTFs are typically the size of a postage stamp and disintegrate on a patient's tongue in a matter of seconds for the rapid release of one or more APIs. The formulation of dissolvable films is customarily facilitated through aqueous polymer matrices that span a wide molecular weight (MW) range, thereby providing flexibility to achieve certain physical properties. With the selection of appropriate polymer excipients, these properties can be tailored to meet specific API-loading needs and dissolution rates.
 
Market Analysis:

Approximately 54% of these products are oral transmucosal thin films. These films can be administered through sublingual, buccal or oral mucosal route, providing advantage of rapid onset of action. There are 10 prescription oral thin films currently in the market. In addition, there are 29 such films which are currently in different stages of clinical / pre-clinical development. Of these, six products are expected to get launched in 2015 / 2016 in their respective geographies.

International Symposium and Workshops

List of Best International Conferences:

  1. 8th Pharmaceutics and Novel Drug Delivery Systems Conference 
    March 07-09, 2016 Madrid, Spain
  2. 9th World Drug Delivery Summit June 30-July 02, 2016 New Orleans, USA
  3. Industrial Pharmacy Conference April 28-29, 2016 Dubai, UAE
  4. 2nd Pharmacology and Ethnopharmacology Conference 
    May 02-04, 2016 Chicago, USA
  5. 4th European Pharma Congress June 13-15, 2016 Berlin, Germany
  6. 7th Annual Global Pharma Summit June 20-22, 2016 New Orleans, USA
  7. 6th Asia-Pacific Pharma Congress July 14-16, 2016 Kuala Lumpur, Malaysia
  8. Nanomedicine Conference July 25-27, 2016 Bangkok, Thailand
  9. 3rd Pharmacology Congress August 08-10, 2016 Birmingham, UK
  10. 2nd Clinical Trials Conference August 22-24, 2016 Philadelphia, USA
  11. 4th Neuropharmacology Conference September 15-17, 2016 San Antonio, USA
  12. 7th Pharmacovigilance and Clinical Trials Conference 
    September 19-21, 2016 Vienna, Austria
  13. 5th Toxicology and Applied Pharmacology Conference 
    September 19-21, 2016 Las Vegas, USA
  14. 2nd Pharma Middle East Congress October 12-14, 2016 Dubai, UAE
  15. Marine Drugs and Natural Products Conference 
    July 28-30, 2016 Brisbane, Australia
  16. 2nd Parenterals and Injectables Conference October 24-26, 2016 Istanbul, Turkey
  17. Drug Delivery Partnerships 2016 (DDP 2016) January 20-22, 2016 Florida, USA
  18. Pharmapack Europe February 10-11, 2016, Paris Expo Porte De Versailles
  19. 7th Annual Global Drug Delivery & Formulation Summit 
    May 23-25, 2016 Berlin, Germany
  20. Peptide Drug Design & Delivery Summit 
    February 24-25, 2016 San Francisco, CA
  21. 6th American Drug Delivery & Formulation Summit 
    June 12-14, 2016 Hilton San Diego Resort & Spa
  22. Respiratory Drug Delivery (RDD 2016) April 17-21, 2016 Phoenix, Arizona

Relevant Society and Associations:

Companies:

This page will be updated regularly.

This page was last updated on 11th Sep, 2015

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