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As per available reports about 7 Relevant journals and 420 Conference proceedings are presently dedicated exclusively to septic arthritis and about 285 Open access articles , 45 National symposiums are being published on septic arthritis.
Septic arthritis is also known as infectious arthritis in which inflammation of joint occurs due to infection. In general septic arthritis affects one large joint in the body. Septic arthritis is usually caused by bacteria that spread through the blood stream. In adult’s haemophilus influenza, staphylococcus and streptococcus bacteria cause septic arthritis. People with open wounds are at high risk for this septic arthritis.
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Scope and Importance:
Septic Arthritis Conference provides the scope for opportunities to learn progressed by international scientists and academicians. Septic Arthritis Conference offers excessive quality content to suit the diverse professional development of these medicines to treat people all over the globe. It is a perfect platform to discuss the current discoveries and developments in the field of Orthopedics and Rheumatology.
Septic, or infectious, arthritis is infection of one or more joints by microorganisms. Normally, the joint is lubricated with a small amount of fluid that is referred to as synovial fluid or joint fluid. The normal joint fluid is sterile and, if removed and cultured in the laboratory, no microbes will be detected. With septic arthritis, microbes are identifiable in an affected joint fluid. Septic Arthritis conference provides the platform for researchers, scholars and educators to present and discuss the most recent innovations, trends, and concerns, practical challenges encountered and the solutions adopted in the field of Orthopedics and Rheumatology.
Septic arthritis is the purulent invasion of a joint by an infectious agent which produces arthritis. People with artificial joints are more at risk than the general population but have slightly different symptoms, are infected with different organisms and require different treatment. Septic arthritis is considered a medical emergency. If untreated, it may destroy the joint in a period of days. The infection may also spread to other parts of the body. The term "suppurative arthritis" is a near synonym for septic arthritis. Reactive arthritis refers to arthritis caused by an immune consequence of an infection, but not directly attributable to the infection itself. Septic arthritis is usually caused by bacteria, but may be caused by viral, mycobacterial, and fungal pathogens as well. A broader term is "infectious arthritis", which describes arthritis caused by any infectious organism. Viruses can cause arthritis, but it can be hard to determine if the arthritis is directly due to the virus or if the arthritis is reactive.
Septic/suppurative arthritis and "bacterial arthritis" are sometimes considered equivalent, but there are exceptions. Septic arthritis can cause pain with any movement of the affected joint. Therefore, those affected by septic arthritis will often refuse to use the extremity and prefer to hold joint rigidly. Other common signs and symptoms are joint swelling, redness, and warmth. Bacteria are carried by the bloodstream from an infectious focus elsewhere, introduced by a skin lesion that penetrates the joint, or by extension from adjacent tissue (e.g. bone or bursae bovine tb).
Micro-organisms must reach the synovial membrane of a joint. This can happen in any of the following ways:
• dissemination of pathogens via the blood, from abscesses or wound infections, or from an unknown focus
• dissemination from an acute osteomyelitic focus
• dissemination from adjacent soft tissue infection
• entry via penetrating trauma
• Entry via iatrogenic means
Septic Arthritis should be considered whenever one is assessing a patient with rapid onset of joint pain. Usually only one joint is affected (monoarthritis) however in seeding arthritis, several joints can be affected simultaneously; this is especially the case when the infection is caused by staphylococcus or gonococcus bacteria. In the case of gonorrhea the knee or wrist may be chronically affected. The pain may be chronic and the physician may inject steroids to reduce symptoms. Weeks later increased pain, redness and swelling- signs of inflammation- appear leading to drainage by needle puncture. Then the gram stain and cultures are typical of a Neisserian infection. The diagnosis of septic arthritic can be difficult as no test is able to completely rule out the possibility. A number of factors should increase one's suspicion of the presence of an infection. In children these included in Kocher criteria.
Diagnosis is by aspiration (giving a turbid, non-viscous fluid), Gram stain and culture of fluid from the joint, as well as tell-tale signs in laboratory testing (such as a highly elevated neutrophils (approx. 90%), ESR or CRP). The diagnosis of septic arthritis is based on clinical assessment and should prompt arthrocentesis. Imaging can sometimes be used to aid in the diagnosis of septic arthritis. Native X-ray of the joint is neither sensitive nor specific. Ultrasound can detect joint-swelling. MRI findings include: synovial enhancement, perisynovial edema and joint effusion. Signal abnormalities in the bone marrow can indicate a concomitant osteomyelitis. The sensitivity and specificity of MRI for the detection of septic arthritis has been reported to be 67% and 98%, respectively.
Therapy is usually with intravenous antibiotics, analgesia and washout/aspiration of the joint to dryness. Among pediatric patients with an acute hematogenous septic arthritis a short total course of 10 days of antimicrobials is sufficient in uncomplicated cases. In infection of a prosthetic joint, a biofilm is often created on the surface of the prosthesis which is resistant to antibiotics. Surgical debridement or arthrotomy is usually indicated in these cases. Replacement prosthesis is usually not inserted at the time of removal to allow antibiotics to clear infection of the region.Patients in whom surgery is contraindicated may trial long-term antibiotic therapy.Close follow up with physical exam & labs must be done to make sure patient remain afebrile, pain resolved, improved range of motion and normalized lab values.
Septic Arthritis market in the leading geographies of the world the US, the UK, Germany, France, Italy, Spain, and Japan. global bone and joint infections therapeutics market was worth $0.7 billion in 2009 and this is forecast to grow at a Compound Annual Growth Rate (CAGR) of 8.1% over the next seven years to reach $1.2 billion by 2016.Global arthritis market is driven by increase in incidences of arthritis patients, global ageing population and increasing healthcare expenditure by government of various nations. Factors which are affecting pharmaceutical companies are pricing pressure, patent expiries of arthritis drugs, high costs of treatments involved and escalating R&D costs. The market is characterized by use of auto-injectors by patients for arthritis treatment, increase in arthritis cases in women and FDA approvals for arthritis drugs. The market for arthritis therapeutics is expected to increase from $56.6 billion in 2013 to $80.7 billion in 2020, at a Compound Annual Growth Rate (CAGR) of 5.2%. The global Arthritis treatment market is expected to increase in value, from $14.3 billion in 2013 to just over $19 billion by 2020, at a Compound Annual Growth Rate (CAGR) of 4.1% according to GBI research.
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Relevant Society and Associations
1. Arthritis Research UK
2. The Arthiritis Society
3. Arthiritis Foundation
4. Arthiritis Research UK
5. Arthiritis Intospective
6. Arthiritis Care
8. Arthiritis Australia
9. Arthiritis Ireland
10. The Arthiritis Association
11. Arthiritis Health Professions Association
12. American Arthritis Society
13. Canadian Arthritis Society
14. National Rheumatoid Arthritis Society
15. American Arthritis Society
16. Arthritis the Chartered Society of Physiotherapy
17. Ontario - The Arthritis Society
18. Australian Orthopaedic Association
19. American Association of Orthopaedic Surgeons
20. American Association for Surgery of Trauma
1. Fierce Pharma
3. Web Md
5. Korizon Pharma
6. Janssen Biotech
7. Georgia Tech Research Institute
8. Arthiritis & Osteoporosis Nsw
10. Joint Health
11. Sandoz GmbH
13. F. Hoffmann-La Roche Ltd.
15. Bayer AG
16. Teva Pharmaceutical Industries Limited
17. Hospira, Inc.
18. LEO Pharma A/S
19. APP Pharmaceuticals, Inc.
20. Abbott Laboratories
21. Eli Lilly and Company,
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This page was last updated on 18th Sep, 2015
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