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Giant Cell Tumor
As per available reports about 57 relevant journals, 2516 Open Access Articles, 5620 Conferences proceeding, 705 National symposiums are presently dedicated exclusively to Cancer therapy and about 25 articles are being published on Giant Cell Tumor.
Giant cell tumors of the tendon sheath are the second most common tumors of the hand, with simple ganglion cysts being the most common. Giant cell tumors of the tendon sheath are usually painless masses that have been present for a long time. The reported duration of symptoms ranges from weeks to as long as 30 years. These tumors usually cause no symptoms, except for occasional distal numbness; however, mild disability may result from impaired function of the digit secondary to the size of the lesion. Giant cell tumors of the tendon sheath are the second most common tumors in the hand; simple ganglion cysts are the most common. Giant cell tumors of the tendon sheath most commonly occur in patients aged 30-50 years, with a peak incidence in those aged 40-50 years. Rarely are these tumors found in patients younger than 10 years or older than 60 years. The female-to-male ratio is 3:2. Giant cell tumors of the tendon sheath are associated with degenerative joint disease, especially in the distal interphalangeal (DIP) joint. Noted degenerative joint disease in the joint from which a tumor arose or in the joint nearest to the mass in 46 of 91 cases in which radiographs were observed. Antecedent trauma occurs in a variable number of these patients, but its association with these tumors is also probably coincidental. The etiology of giant cell tumors of the tendon sheath is unknown. Pathogenetic theories have included trauma, disturbed lipid metabolism, osteoclastic proliferation, infection, vascular disturbances, immune mechanisms, inflammation, neoplasia, and metabolic disturbances is that of a reactive or regenerative hyperplasia associated with an inflammatory process. Histochemical evidence shows that the mononuclear cells and giant cells present in these lesions resemble osteoclasts suggesting a bone marrow–derived monocyte/macrophage lineage for these tumors. Recent polymerase chain reaction (PCR) assays have shown that giant cell tumors of the tendon sheath are polyclonal proliferations that these masses are non-neoplastic proliferations, if one accepts the premise that a population of cells forming a tumorous mass must show clonality to be classified as a neoplasm.
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This page was last updated on 14th Sep, 2015
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