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As per available reports about 10 Conference proceedings and 4 relevant journals are published by OMICS International relevant to Connective Tissue Disease.
Connective Tissue Disease is any disease that has the connective tissues of the body as a target of pathology. Connective tissue disease includes broad range of study like Cartilage biology and repair, Rheumatic Disorders and Treatment, Various Hematologic Malignancies and their treatments which may cover another wide ranged subject, Types of leukemia.
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Connective tissue disease states to a group of disorders concerning the protein-rich tissue that supports organs and other parts of the body. Examples of connective tissue are fat, bone, and cartilage. These disorders often involve the joints, muscles, and skin, but they can also involve other organs and organ systems comprising the eyes, heart, lungs, kidneys, gastrointestinal tract, and blood vessels. There are more than 200 disorders that affect the connective tissue. Causes and precise symptoms vary by the different types. Some connective tissue diseases often called heritable disorders of connective tissue (HDCTs) are the outcome of changes in certain genes. Many of these are quite rare. Some of them are Ehlers-Danlos syndrome (EDS), Epidermolysis bullosa (EB), Marfan syndrome and Osteogenesis imperfect. For other forms of connective tissue disease, the cause is not known. In these diseases, the body's normally protective immune system produces antibodies that target the body's own tissues. These diseases includes Polymyositis, dermatomyositis, Rheumatoid arthritis (RA), Scleroderma, Sjögren's syndrome and Systemic lupus erythematosus.
Connective tissue is any type of biological tissue with an extensive extra cellular matrix that supports, binds together, and protects organs. These tissues form a framework, or matrix, for the body, and are composed of two major structural protein molecules: collagen and elastin. There are many different types of collagen protein in each of the body's tissues. Elastin has the capability of stretching and returning to its original length like a spring or rubber band. Elastin is the major component of ligaments (tissues that attach bone to bone) and skin. In patients with connective tissue disease, it is common for collagen and elastin to become injured by inflammation. Many connective tissue diseases feature abnormal immune system activity with inflammation in tissues as a result of an immune system that is directed against one's own body tissues (autoimmunity). There are more than 200 disorders that affect the connective tissue. Some connective tissue diseases often called heritable disorders of connective tissue (HDCTs) are the result of changes in certain gene. Many of these are quite rare. Following are some of the more common ones: Ehlers-Danlos Syndrome (EDS), Epidermolysis Bullosa, Marfan syndrome, Osteogenesis Imperfecta, etc. Some of the common Autoimmune Tissue Disease are as follows: Polyositis and dermatomyositis, Rheumatoid Arthritis, Scleroderma, Sjogren’s Syndrome, Systemic Lupus Erythematosus, Vasculitis, Mixed Connective Tissue Disease, etc.
The prevalence and incidence of connective tissue disorders reported are quite variable based on differences in study procedure. Most significant differences are the study duration, the classification criteria used for diagnosis and the country in which the study was undertaken. Sjögren's syndrome has the highest occurrence ranging between 0.5 and 3% of a given population. The incidence of systemic lupus erythematosus (SLE) is estimated between 15 and 50 per 100 000 persons, with a female to male ratio of 10:1 in the age group between 15 and 40 years. The occurrence of systemic sclerosis is lower, however, varying considerably between different studies and countries. The occurrence of overlap syndromes, particularly mixed connective tissue disease, is unknown, and polymyositis and dermatomyositis are observed as very rare rheumatic diseases. Though the classification criteria for the connective tissue disorders have not been established for the purpose of diagnosing an individual patient, these criteria still are the most valuable tool for the identification of patients with systemic rheumatic diseases such as connective tissue disorders.
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This page was last updated on 12th Sep, 2015
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