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Cancer Cell Lines
As per available reports about 57 relevant journals,2516 Open Access Articles,5620 Conferences proceeding, 705 National symposiums are presently dedicated exclusively to Cancer therapy and about 25 articles are being published on Cancer Cell Lines.
Cancer cells that keep dividing and growing over time, under certain conditions in a laboratory. Cancer cell lines are used in research to study the biology of cancer and to test cancer treatments. The Cancer Cell Line is a compilation of gene expression, chromosomal copy number and massively parallel sequencing data from 947 human cancer cell lines. When coupled with pharmacological profiles for 24 anticancer drugs across 479 of the cell lines, this collection allowed identification of genetic, lineage, and gene-expression-based predictors of drug sensitivity. The plasma cell lineage correlated with sensitivity to IGF1 receptor inhibitors; AHR expression was associated with MEK inhibitor efficacy in NRAS-mutant lines; and SLFN11 expression predicted sensitivity to topoisomerase inhibitors. Together, our results indicate that large, annotated cell-line collections may help to enable preclinical stratification schemata for anticancer agents. The generation of genetic predictions of drug response in the preclinical setting and their incorporation into cancer clinical trial design could speed the emergence of ‘personalized’ therapeutic regimens. The comparison of copy-number changes, mutations and mRNA expression profiles reveals pronounced differences in molecular profiles between commonly used ovarian cancer cell lines and high-grade serous ovarian cancer tumour samples. The major criticism of cell lines is that not all cancer types can be grown indefinitely in the laboratory. Those that do grow differ genetically from primary tissue, accumulating new mutations as they adapt to their artificial environment. When implanted in rodents, brain-cancer cell lines tend to form a 'bowling ball' mass of cells rather than infiltrating the brain like a spider web, as they do in humans. But primary cells are more expensive to sequence because, unlike cell lines, they contain a mixture of genetically distinct cells, so researchers need to use costly techniques to pinpoint rare mutations that are not spread uniformly throughout the tumour.
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Relevant Conferences:
4th Blood Malignancies and Treatment Conference April 18-20, 2016 Dubai, UAE
2nd Prostate Cancer and Treatment Conference May 05-07, 2016 Chicago, USA
2nd Antimicrobial Agents and Chemotherapy Conference June 06-07, 2016 Dallas, USA
Relevant Associations:
• American Cancer Society
• Breast Cancer Association Consortium (BCAC)
• American Association for Cancer Research (AACR)
• Prostate Cancer Foundation (PCF)
• Indo-American Cancer Association (IACA)
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This page was last updated on April 19, 2024