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Autosomal Dominant

Dominance in genetics is a relationship between alleles of one gene, in which one allele is expressed over a second allele at the same locus. The first allele is dominant and the second allele is recessive. For genes on an autosome (any chromosome other than a sex chromosome), the alleles and their associated traits are autosomal dominant or autosomal recessive. Dominance is a key concept in Mendelian inheritance and classical genetics. Often the dominant allele codes for a functional protein whereas the recessive allele does not.

A classic example of dominance is the inheritance of seed shape (pea shape) in peas. Peas may be round (associated with allele R) or wrinkled (associated with allele r). In this case, three combinations of alleles (genotypes) are possible: RR, Rr, and rr. The RR individuals have round peas and the rr individuals have wrinkled peas. In Rr individuals the R allele masks the presence of the r allele, so these individuals also have round peas. Thus, allele R is dominant to allele r, and allele r is recessive to allele R (this use of upper case for dominant alleles and lower case for recessive alleles is a widely followed convention).

More generally, where a gene exists in two allelic versions (designated A and a), three combinations of alleles (genotypes) are possible: AA, Aa, and aa. If AA and aa individuals (homozygotes) show different forms of some trait (phenotypes), and Aa individuals (heterozygotes) show the same phenotype as AA individuals, then allele A is said to dominate or be dominant to or show dominance to allele a, and a is said to be recessive to A. Dominance is not inherent to an allele. It is a relationship between alleles; one allele can be dominant over a second allele, recessive to a third allele, and co-dominant to a fourth. Dominance differs from epistasis, a relationship in which an allele of one gene affects the expression of another allele at a different gene.

An autosome is a chromosome that is not an allosome (i.e., not a sex chromosome). Autosomes appear in pairs whose members have the same form but differ from other pairs in a diploid cell, whereas members of an allosome pair may differ from one another and thereby determine sex. The DNA in autosomes is collectively known as atDNA or auDNA. For example, humans have a diploid genome that usually contains 22 pairs of autosomes and one allosome pair (46 chromosomes total). The autosome pairs are labeled with numbers (1-22 in humans) roughly in order of their sizes in base pairs, while allosomes are labeled with their letters. By contrast, the allosome pair consists of two X chromosomes in females or one X and one Y chromosome in males. (Unusual combinations of XYY, XXY, XXX, XXXX, XXXXX or XXYY, among other allosome combinations, are known to occur and usually cause developmental abnormalities.

By definition, the terms dominant and recessive refer to the genotypic interaction of alleles in producing the phenotype of the heterozygote. The key concept is genetic: Which of the two alleles present in the heterozygote is expressed, such that the organism is phenotypically identical to one of the two homozygotes. It is sometimes convenient to talk about the trait corresponding to the dominant allele as the dominant trait, and the trait corresponding to the hidden allele as the recessive trait. However, this can easily lead to confusion in understanding the concept as phenotypic. For example, to say that "green peas" dominate "yellow peas" confuses inherited genotypes and expressed phenotypes, and will subsequently confuse discussion of the molecular basis of the phenotypic difference. Dominance is not inherent. One allele can be dominant to a second allele, recessive to a third allele, and co-dominant to a fourth. Dominance is unrelated to the nature of the phenotype itself, that is, whether it is regarded as "normal" or "abnormal," "standard" or "nonstandard," "healthy" or "diseased," "stronger" or "weaker," or more or less extreme. A dominant allele may account for any of these trait types. Other distinctions are made between the gene locus (e.g. "A gene influencing seed shape"), the alleles at that locus (e.g. the "round" or "wrinkled alleles"), and the phenotype the alleles produce (e.g. "round" or "wrinkled").

OMICS Group International is an amalgamation of Open Access publications and worldwide international science conference and events established in the year 2007 with the sole aim of making the information on Sciences and technology ‘Open Access’. OMICS Group publishes 400 online open access scholarly journals in all aspects of Science, Engineering, Management and Technology. OMICS has 21 days rapid review process involving 30,000 editorial team members with 3.5 Million readers. OMICS ‘Open Access’ has been instrumental in taking the knowledge on science & technology to the doorsteps of ordinary men and women. Research scholars, students, libraries, educational institutions, research centers and the industries are main stakeholders that benefit greatly from this knowledge dissemination. OMICS Group also organizes 300 International Conferences annually across the globe, where knowledge transfer takes place through debates, round table discussions, poster presentations, International workshops, International symposia and exhibitions.

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This page was last updated on 17th Sep, 2015

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