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As per available reports about 43 Relevant Journals, 43 Conferences, 1 National Symposium are presently dedicated exclusively to pulsative drug delivery and about 156 articles are being published on pulsative drug delivery.
Pulsatile drug delivery system is defined as the rapid and transient release of certain amount of drug molecules within a short time period immediately after a predetermined off- release period i.e., lag time. Pulsatile drug delivery aims to release drug on programmed pattern i.e. at appropriate time and at appropriate site of action. Pulsatile systems are gaining a lot of interest as the drug is released completely after defined lag time. Pulsatile drug delivery system is time- and site-specific drug delivery system, thus providing special and temporal delivery and increasing patient compliance.
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Scope and Importance:
Pulsatile-release formulations have many advantages over immediate-release formulations. With these formulations, less-frequent drug administration is possible, and patient compliance can correspondingly be improved. In the field of drug delivery, increased attention has recently been focused on the potential of systems that are able to release drugs after a programmable lag phase commencing at administration time, i.e., in a pulsatile mode. During the last two decades, technologies to ensure time-controlled pulsatile release of bioactive compounds have been developed. Significant progress has been made towards achieving pulsatile drug delivery systems that can effectively treat diseases with non-constant dosing therapies, such as diabetes. However, there is much work that needs to be carefully demonstrated for the pulsatile delivery of bioactive compounds, especially hormones.
Delivery systems with a pulsatile-release pattern are receiving increasing interest for the development of drugs for which conventional controlled drug-release systems with a continuous release are not ideal. These drugs often have a high first-pass effect or special chronopharmacological needs. A pulsatile-release profile is characterized by a time period of no release (lag time) followed by a rapid and complete drug release. Pulsatile drug-delivery systems can be classified into site-specific systems in which the drug is released at the desired site within the intestinal tract (e.g., the colon), or time-controlled devices in which the drug is released after a well-defined time period. Site-controlled release is usually controlled by environmental factors, like the pH or enzymes present in the intestinal tract, whereas the drug release from time-controlled systems is controlled primarily by the delivery system and, ideally, not by the environment. This review covers various single- and multiple-unit oral pulsatile drug-delivery systems with an emphasis on time-controlled drug-release systems.
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This page was last updated on 11th Sep, 2015
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