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Bilayer Tablets


Bilayer Tablets

As per available reports about 43 relevant Journals, 54 Conferences, 26workshops are presently dedicated exclusively to bilayer tabletsand about 3,875articles are being published on bilayer tablets.

Bilayer tablets are new novel of tablets for the successful development of controlled release formulation along with many features to provide a way of successful drug delivery system. Bilayer tablets have been developed to achieve modified release of drug. Bilayer tablets are suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one Layer is immediate release as initial dose and second layer is maintenance dose. So use of bilayer tablets is a very different aspect for anti-hypertensive, diabetic, anti-inflammatory and analgesic drugs where combination therapy is often used.   Bilayer tablet is improved beneficial technology to overcome the shortcoming of the single layered tablet. In the case of bilayer tablets drug release can be rendered almost unidirectional if the drug can be incorporated in the upper non adhesive layer its delivery occurs into the whole oral cavity. To reduce capital investment, quite often existing but modified tablet presses are used to develop and produce such tablets. The present article explains why the production and development of quality bi-layer tablets needs to be carried out on purpose-built tablet presses to overcome common bi-layer problems, such as hardness, insufficient, layer-separation, inaccurate individual layer weight control, reduced yield, cross-contamination between the layers, etc. Using a modified tablet press may therefore not be your best approach to producing a quality bi-layer tablet under GMP-conditions.

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Scope and Importance:

Bilayer tablets offer an excellent opportunity for manufacturers to separate themselves from their competitors, improve their products’ efficacy, and protect against impersonator products. Bi-layer tablet quality and GMP requirements can vary widely. This explains why many different types of presses are being used to produce bi-layer tablets, ranging from simple single-sided presses to highly sophisticated machines. When a quality bi-layer tablet needs to be produced in conjunction with accurate weight control of both layers, compression force-controlled presses are clearly limited because of their insufficient sensitivity and hence lack of accuracy at low compression forces required to secure interlayer bonding.

Bilayer tablets are prepared with one layer of drug for immediate release with the second layer designed to release drug later, either as a second dose or in an extended release forms. The bilayer tablets with two incompatible drugs can also be prepared by compressing separate layers of each drug so as to minimize area of contact between two layers. An additional intermediate layer of inert material may also be included. To produce adequate tablet formulation, certain requirements such as sufficient mechanical strength and desired drug release profile must be met. At times, this may be difficult task for formulator to achieve these conditions especially in bilayer tablet formulation where double compression technique is involved, because of poor flow and compatibility characteristic of the drug which will result in capping and/or lamination. The compaction of a material involves both the compressibility and consolidation.
 

Market Analysis:

According to IMS Health Consulting, an international research company, in 2012 the size of the global pharmaceutical market reached $940 billion. In monetary terms it grew by 6%. In the future the sector is expected to grow at no less than 3% to 4% a year and if this happens the global pharmaceutical market is expected to reach $1.1 trillion by 2015 and will reach $1.2 trillion in 2016 and up to $1.5 trillion by 2020. The global demographic, epidemiological and economic changes are transforming the pharmaceutical market. The world population is growing rapidly and is projected to raise from 7 billion in 2011 to 7.7 billion in 2020 and 9.6 billion in 2050, hence an increase in the demand for pharmaceuticals.

International symposium and workshops

1. 5th PCNE Working Symposium 2016, Hillerød, Denmark, 19-20 February 2016.

2. 8th Pharma Sciences symposium, Osaka, Japan, 21-22 January 2016.

3. ISOPP 2016, Santiago, Chile, April 17-20, 2016.

List of Best International Conferences      

  1. Nanomedicine and Nanotechnology in Healthcare Conference,
     July 25-27, 2016 Bangkok, Thailand
  2. 6thPharmacovigilance Conference Congress
    August 01-03, 2016 Toronto, Canada
  3. 3rd World Congress on Pharmacology
    August 08-10, 2016 Birmingham, UK
  4. 2ndClinical Trials Conference 
    August 22-24, 2016 Philadelphia, USA
  5. 7th Bioavailability & Bioequivalence: BA/BE Studies Summit  
    August 29-31, 2016 Atlanta, USA
  6. Brazil Pharma Expo August 29-31, 2016 Sao Paulo, Brazil
  7. 5thBiologics and Biosimilars Conference
    September 12-14, 2016 San Antonio, USA
  8. 6thPharmaceutical Regulatory Affairs and IPR Conference
    September 12-14, 2016 San Antonio, USA
  9. 4th Neuropharmacology Conference
    September 15-17, 2016 San Antonio, USA
  10. 7thPharmacovigilance & Clinical Trials Conference
    September 19-21, 2016 Vienna, Austria
  11. 3rdPast and Present Research Systems of Green Chemistry Conference September 19-21, 2016 Las Vegas, USA
  12. 5thToxicology&Applied Pharmacology Conference
    September 19-21, 2016 Las Vegas, USA
  13. 7th Analytical & Bioanalytical Techniques Conference
    Sept 29-Oct 01, 2016 Miami, USA
  14. Global Pharma Expo
    October 10-12, 2016 Dubai, UAE
  15. Marine Drugs and Natural Products Conference
    July 28-30, 2016 Brisbane, Australia
  16. 2ndParenterals&Injectables Conference
    October 24-26, 2016 Istanbul, Turkey
  17. 4thClinical Pharmacy Conference
    Oct 31 - Nov 01, 2016 Las Vegas, USA
  18. 2ndDrug Discovery & Designing Conference
    Oct 31-Nov 02, 2016 Istanbul, Turkey
  19. Pharma Marketing Conference
    November 17-19, 2016 Alicante, Spain
  20. Medicinal Chemistry & Computer Aided Drug Designing Conference December 01-03, 2016 Chicago, USA
  21.  2ndAnnual Pharma Middle East Congress 
    October 12-14, 2016 Dubai, UAE
  22. ICPSP 2016 : 18th International Conference on Pharmaceutical Sciences and Pharmacology
    January 21 - 22, 2016, Paris, France
  23. American Society for Clinical Pharmacology and Therapeutics 2016 Annual Meeting
    March 9-12, 2016, California, United States
  24. Dubai International Pharmaceuticals and Technologies Conference and Exhibition
    2016, 15-17 March 2016, Dubai, UAE
  25. 7th International Conference on Drug Discovery and Therapy
     February 15th - 18th, 2016, Dubai, UAE
  26. 2016 Independent Pharmacy Business Growth Conference
     February 24-27, 2016, Orlando, FL
  27. APS 6th International PharmSci Conference 2016
    5 - 7 September 2016, Glasgow

Relevant Society and Associations

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This page will be updated regularly.

This page was last updated on 10th Sep, 2015

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